{"id":9622,"date":"2026-04-09T09:02:16","date_gmt":"2026-04-09T07:02:16","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9622"},"modified":"2026-10-01T09:06:40","modified_gmt":"2026-10-01T07:06:40","slug":"hif1-%ce%b1-induces-mitochondrial-fission-in-trophoblastic-cells-during-early-pregnancy-and-in-preeclampsia","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/hif1-%ce%b1-induces-mitochondrial-fission-in-trophoblastic-cells-during-early-pregnancy-and-in-preeclampsia\/","title":{"rendered":"HIF1-\u03b1 induces mitochondrial fission in trophoblastic cells during early pregnancy and in preeclampsia"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The placenta undergoes a major oxygen transition between 7 and 9 gestation weeks (GW) and 12-14 GW. Inadequate adaptation to these environmental changes leads to oxidative stress and the release of syncytial knots, a hallmark of preeclampsia (PE). As mitochondria play a central role in redox regulation, we investigated mitochondrial network dynamics and the role of hypoxia-inducible factor 1-alpha (HIF1-\u03b1) in trophoblasts during early pregnancy and in PE. HIF1-\u03b1 is stabilized in placenta before 9 GW, associated with mitochondrial hypertubulation and increased mitofusin (MFN) 1 expression. Experimental stabilization of HIF1-\u03b1 using cobalt chloride induces mitochondrial fission through downregulation of MFN1 and MFN2, and upregulation of dynamin-related protein 1 (DRP1). In pre-eclamptic placentas, significantly elevated mitochondrial fission 1 protein (FIS1) levels suggest enhanced mitochondrial fission, supporting FIS1 as a potential biomarker of PE-associated placental alterations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>iScience. 2026 Apr 9;29(5):115674.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9622","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HIF1-\u03b1 induces mitochondrial fission in trophoblastic cells during early pregnancy and in preeclampsia - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/hif1-%ce%b1-induces-mitochondrial-fission-in-trophoblastic-cells-during-early-pregnancy-and-in-preeclampsia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HIF1-\u03b1 induces mitochondrial fission in trophoblastic cells during early pregnancy and in preeclampsia - 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