{"id":9513,"date":"2026-07-21T14:23:11","date_gmt":"2026-07-21T12:23:11","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9513"},"modified":"2026-08-06T14:27:12","modified_gmt":"2026-08-06T12:27:12","slug":"dysbiosis-induced-expansion-of-axl-positive-inflammatory-type-3-dendritic-cells-triggers-preclinical-autoimmunity","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/dysbiosis-induced-expansion-of-axl-positive-inflammatory-type-3-dendritic-cells-triggers-preclinical-autoimmunity\/","title":{"rendered":"Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Conventional dendritic cells (cDCs) are key sentinels at epithelial barriers, regulating immunity to microbial pathogens and commensals while preserving tissue integrity. NOTCH2 deficiency in CD11c-expressing cells (Notch2<sup>cKO<\/sup>) disrupts type 2a DC (cDC2a) development, impairs intestinal T<sub>H<\/sub>17 immunity and increases susceptibility to enteropathogenic bacteria. This defect leads to persistent dysbiosis in Notch2<sup>cKO<\/sup> mice, characterized by low-grade inflammation and systemic autoimmune features, including elevated autoantibody titers and renal immune complex deposition. Dysbiosis precedes expansion of highly inflammatory AXL-expressing type 3 DCs (AXL<sup>+<\/sup>inf-DC3), promoting chronic inflammation and tertiary lymphoid structures driving adaptive immune responses. Notably, dysbiosis is defined by three dominant pathobionts and is transferable to wild-type mice, recapitulating the autoimmune features observed in Notch2<sup>cKO<\/sup> mice. Here these findings identify a microbiota-DC axis linking intestinal pathobionts to systemic autoimmunity, establishing inflammatory DC3 as the cellular bridge between dysbiosis, chronic inflammation and autoimmune pathogenesis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nat Immunol. 2026 Jul 21. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9513","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/dysbiosis-induced-expansion-of-axl-positive-inflammatory-type-3-dendritic-cells-triggers-preclinical-autoimmunity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity - 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