{"id":9392,"date":"2026-05-04T15:27:38","date_gmt":"2026-05-04T13:27:38","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9392"},"modified":"2026-06-05T15:29:04","modified_gmt":"2026-06-05T13:29:04","slug":"calibration-and-discrimination-ability-of-the-dataids-score-in-people-living-with-hiv-aged-70-years-and-older-from-the-dataids-cohort","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/calibration-and-discrimination-ability-of-the-dataids-score-in-people-living-with-hiv-aged-70-years-and-older-from-the-dataids-cohort\/","title":{"rendered":"Calibration and discrimination ability of the Dat&#8217;AIDS score in people living with HIV aged 70 years and older from the Dat&#8217;AIDS cohort"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<p><strong>Objective:<\/strong> The Dat&#8217;AIDS score was developed to predict 5-year mortality risk in people living with HIV aged 60 and older. However, its validity in people living with HIV aged 70 years and older needed confirmation.<\/p>\n\n\n\n<p><strong>Methods:<\/strong> This was a multicentre prospective cohort study in the Dat&#8217;AIDS French cohort. We calculated the Dat&#8217;AIDS score and Veterans Aging Cohort Study (VACS) indices 1.0 and 2.0 in people living with HIV aged 70 or older, at their first medical visit between 01\/06\/2014 and 31\/12\/2017. Participants were followed until 31 December 2019 (before the COVID-19 era). Discrimination and calibration of the Dat&#8217;AIDS score were assessed using Harrell&#8217;s C-statistic and comparisons of predicted versus observed survival probabilities. The comparison of the discriminative capacity of the Dat&#8217;AIDS score with the VACS indices was performed.<\/p>\n\n\n\n<p><strong>Results:<\/strong> A total of 1330 participants (75.5% male, median age: 73.7 years, median time since HIV diagnosis: 21.7 years, median time under combination antiretroviral therapy (cART): 19.9 years, median CD4 cell count: 553 cells\/\u03bcL, HIV-1 RNA \u226450 copies\/mL: 88.7%) were included. Overall, 221 (16.6%) deaths were recorded during 5598 patient-years of follow-up. The Dat&#8217;AIDS score showed good discrimination (C-statistic: 0.72; 95% confidence interval [CI; 0.68-0.75]). Calibration was good except for the moderate-risk group (5% difference). The Dat&#8217;AIDS score showed better discrimination than VACS 1.0 and 2.0 with albumin, aspartate aminotransferase (AST) and alanine transaminase (ALT) normal value imputation (C-statistic: 0.72 vs. 0.69 for both) and was similar to VACS 2.0 without imputation (0.72 vs. 0.71), that could be calculated in 99.1%, 98.6% and 34.0%, respectively.<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> The Dat&#8217;AIDS score showed good discrimination and calibration in people living with HIV aged 70 years and older, providing an easy and valuable tool for clinical decision-making and research.<\/p>\n\n\n\n<p><strong>Keywords:<\/strong> DAT&#8217;AIDS; HIV infection; aged; cohort; validation study<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Group. HIV Med. 2026 May;27(5):771 784.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9392","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Calibration and discrimination ability of the Dat&#039;AIDS score in people living with HIV aged 70 years and older from the Dat&#039;AIDS cohort - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/calibration-and-discrimination-ability-of-the-dataids-score-in-people-living-with-hiv-aged-70-years-and-older-from-the-dataids-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calibration and discrimination ability of the Dat&#039;AIDS score in people living with HIV aged 70 years and older from the Dat&#039;AIDS cohort - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Group. 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