{"id":9333,"date":"2026-04-02T16:45:48","date_gmt":"2026-04-02T14:45:48","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9333"},"modified":"2026-05-07T16:49:24","modified_gmt":"2026-05-07T14:49:24","slug":"il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/","title":{"rendered":"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We report that in developing zebrafish, enteroendocrine cells produced interleukin-22 (IL-22) in response to microbial signals before lymphocytes populated the gut. In larvae, IL-22 shaped the gut microbiota, increasing Lactobacillaceae abundance and ghrelin expression to promote gut motility. Impaired motility and ghrelin expression were restored in <em>il22<\/em><sup>-\/-<\/sup> zebrafish by transfer of microbiota from wild-type zebrafish or by introducing only <em>Lactobacillus plantarum<\/em>. IL-22-deficient mice also had impaired gut motility and reduced ghrelin expression in early life, indicating a conserved function. Thus, before immune system maturation, enteroendocrine cells regulate early-life gut function by controlling the microbiota through IL-22.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science. 2026 Apr 2;392(6793):69-76. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9333","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Science. 2026 Apr 2;392(6793):69-76.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-07T14:49:24+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/publications\\\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\\\/\",\"url\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/publications\\\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\\\/\",\"name\":\"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/#website\"},\"datePublished\":\"2026-04-02T14:45:48+00:00\",\"dateModified\":\"2026-05-07T14:49:24+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/publications\\\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/publications\\\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/publications\\\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/fhu-premimpact.org\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\\\/\\\/fhu-premimpact.org\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\\\/\\\/fhu-premimpact.org\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.instagram.com\\\/fhupremimpact\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/in\\\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/","og_locale":"en_US","og_type":"article","og_title":"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota - FHU Prem&#039;IMPACT","og_description":"Science. 2026 Apr 2;392(6793):69-76.","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2026-05-07T14:49:24+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/","name":"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2026-04-02T14:45:48+00:00","dateModified":"2026-05-07T14:49:24+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/il-22-from-enteroendocrine-cells-promotes-early-life-gut-motility-in-zebrafish-through-the-microbiota\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota"}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"Science. 2026 Apr 2;392(6793):69-76.","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/9333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=9333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}