{"id":9100,"date":"2026-02-19T14:46:49","date_gmt":"2026-02-19T13:46:49","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9100"},"modified":"2026-03-04T14:49:51","modified_gmt":"2026-03-04T13:49:51","slug":"histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/","title":{"rendered":"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Objective:<\/strong> To assess the association between histological chorioamnionitis without maternal clinical symptoms and neurodevelopmental disabilities at age 5 years in children born very preterm.<\/p>\n\n\n\n<p><strong>Design:<\/strong> French national prospective population-based cohort study, EPIPAGE-2 (<em>Etude \u00e9pid\u00e9miologique sur les petits \u00e2ges gestationnels<\/em>).<\/p>\n\n\n\n<p><strong>Setting:<\/strong> All births from 22 to 34 weeks of gestational age in France in 2011 were eligible.<\/p>\n\n\n\n<p><strong>Population:<\/strong> Infants born alive between 24<sup>+0<\/sup> and 31<sup>+6<\/sup> weeks following preterm labour (PTL) or preterm premature rupture of membranes (PPROMs).<\/p>\n\n\n\n<p><strong>Exposure:<\/strong> Histological chorioamnionitis without maternal clinical symptoms, also called isolated histological chorioamnionitis, was defined as the presence of neutrophils in the chorionic plate, excluding clinical chorioamnionitis.<\/p>\n\n\n\n<p><strong>Main outcome measures:<\/strong> Neurodevelopmental disabilities, a composite outcome including cerebral palsy, developmental coordination disorders, sensory impairment, developmental cognitive deficiencies or behavioural difficulties. These assessments were comprehensive, standardised and conducted by trained neuropsychologists and paediatricians at age 5 years.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Among 1296 children alive at 5 years of age, 486 (36.3%) were born in a context of isolated histological chorioamnionitis. Overall, 47% vs 33.6% of children exposed and not exposed to isolated histological chorioamnionitis had mild neurodevelopmental disabilities, and 13.8% vs 13.3% had moderate-to-severe neurodevelopmental disabilities. After multiple imputation and multivariable analysis, isolated histological chorioamnionitis was found not to be associated with the occurrence of mild or moderate-to-severe neurodevelopmental disabilities (adjusted OR: 1.0, 95% CI: 0.7 to 1.4 and 0.9, 0.6 to 1.2).<\/p>\n\n\n\n<p><strong>Conclusion:<\/strong> We did not find any association between isolated histological chorioamnionitis and neurodevelopmental disabilities at age 5 years in children born very preterm after PTL or PPROM.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>group on infections. Arch Dis Child Fetal<br \/>\nNeonatal Ed. 2026 Feb 19;111(2):F147 F154<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9100","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"group on infections. Arch Dis Child Fetal Neonatal Ed. 2026 Feb 19;111(2):F147 F154\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-04T13:49:51+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/\",\"name\":\"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2026-02-19T13:46:49+00:00\",\"dateModified\":\"2026-03-04T13:49:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/","og_locale":"en_US","og_type":"article","og_title":"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT","og_description":"group on infections. Arch Dis Child Fetal Neonatal Ed. 2026 Feb 19;111(2):F147 F154","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2026-03-04T13:49:51+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/","name":"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2026-02-19T13:46:49+00:00","dateModified":"2026-03-04T13:49:51+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/histological-chorioamnionitis-and-neurodevelopment-at-5-years-of-age-among-infants-born-very-preterm-epipage-2-cohort-study-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study"}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"group on infections. Arch Dis Child Fetal Neonatal Ed. 2026 Feb 19;111(2):F147 F154","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/9100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=9100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}