{"id":9096,"date":"2026-02-02T14:13:41","date_gmt":"2026-02-02T13:13:41","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9096"},"modified":"2026-03-04T14:18:44","modified_gmt":"2026-03-04T13:18:44","slug":"non-invasive-characterization-of-pericyte-dysfunction-in-mouse-brain-using-functional-ultrasound-localization-microscopy","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/non-invasive-characterization-of-pericyte-dysfunction-in-mouse-brain-using-functional-ultrasound-localization-microscopy\/","title":{"rendered":"Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p>Early microscopic-scale pericyte dysfunction contributes to the initial stages of many neurological diseases and represents a strong candidate target for therapeutic intervention. A non-invasive imaging modality able to image microvascular alterations induced by pericyte dysfunction is needed. In addition, the development of pericyte-focused therapies remains challenging due to the lack of early biomarkers of disease progression. Here we show that cerebral microvascular alterations induced by pericyte dysfunction can be characterized non-invasively in mice using functional ultrasound localization microscopy (fULM). Depletion of endothelial endoglin in adult mice as a model of hereditary haemorrhagic telangiectasia, leads to pericyte detachment in the arteriole-capillary transition (ACT) zone. Imaging reveals that arteriolar capillaries have irregular shapes, increased diameters, reduced blood speed and neurovascular uncoupling mainly localized in the ACT zone. Transforming growth factor-\u03b2 signalling activator C381 restores pericyte coverage and neurovascular response. Our study underscores the potential of fULM in characterizing early microvascular alterations. As super-resolution ultrasound transitions to the clinic, our data support its future use in monitoring pericyte-focused therapies in humans.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nat Biomed Eng. 2026 Feb;10(2):214 230.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9096","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/non-invasive-characterization-of-pericyte-dysfunction-in-mouse-brain-using-functional-ultrasound-localization-microscopy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy - 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