{"id":9051,"date":"2026-01-06T12:20:55","date_gmt":"2026-01-06T11:20:55","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=9051"},"modified":"2026-02-09T12:24:22","modified_gmt":"2026-02-09T11:24:22","slug":"suboptimal-visual-acuity-and-neurodevelopment-at-five-years-in-children-born-very-preterm-the-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/suboptimal-visual-acuity-and-neurodevelopment-at-five-years-in-children-born-very-preterm-the-epipage-2-cohort-study\/","title":{"rendered":"Suboptimal visual acuity and neurodevelopment at five years in children born very preterm: the EPIPAGE-2 cohort study"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Introduction:<\/strong> Children born preterm often have anatomical and functional visual abnormalities, even in the absence of retinopathy of prematurity. This includes suboptimal visual acuity (VA), defined as binocular VA between 5-6.3\/10 and 8\/10. We examine relationships between suboptimal VA and neurodevelopment in children born preterm.<\/p>\n\n\n\n<p><strong>Methods:<\/strong> Secondary analysis of the French EPIPAGE-2 cohort with children born between 24+0 weeks and 31+6 weeks of gestation, eligible for follow-up at 5.5 years. Children were classified into three VA groups: 5-6.3\/10, 8\/10 and 10\/10 as reference group. Neurodevelopment was assessed with the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition, the Movement Assessment Battery for Children-II (MABC-2) and the Strengths and Difficulties Questionnaire (SDQ). Comparisons between groups were adjusted for neonatal and socioeconomic characteristics using generalised estimating equations models.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Among 1787 included children, 62% had suboptimal VA. Compared with the 10\/10 VA group, the mean full-scale IQ decreased by -3.09 (95 % CI -4.75 to -1.42) and -4.97 (95 % CI -6.47 to -3.46) points, the mean MABC-2 total score by -0.66 (95 % CI -0.71 to -0.61) and -1.06 (95 % CI -1.09 to -1.00), and the mean total SDQ scores increased by 0.40 (95 % CI -0.16 to 0.94) and 0.60 (95 % CI 0.10 to 1.1) in groups with VA groups at 8\/10 and 5-6.3\/10, respectively.<\/p>\n\n\n\n<p><strong>Discussion:<\/strong> In this French population-based cohort of children born preterm, suboptimal VA was frequent and associated with increased risk of neurodevelopmental difficulties. A comprehensive neurodevelopmental and neurovisual assessment is warranted in children born preterm with suboptimal VA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Arch Dis Child Fetal Neonatal Ed. 2026 Jan 6:fetalneonatal 2025 329163.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-9051","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Suboptimal visual acuity and neurodevelopment at five years in children born very preterm: the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/suboptimal-visual-acuity-and-neurodevelopment-at-five-years-in-children-born-very-preterm-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Suboptimal visual acuity and neurodevelopment at five years in children born very preterm: the EPIPAGE-2 cohort study - 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