{"id":8550,"date":"2025-03-21T16:40:00","date_gmt":"2025-03-21T15:40:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8550"},"modified":"2025-06-30T16:42:23","modified_gmt":"2025-06-30T14:42:23","slug":"trophoblast-fusion-in-hypertensive-disorders-of-pregnancy-and-preeclampsia","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/trophoblast-fusion-in-hypertensive-disorders-of-pregnancy-and-preeclampsia\/","title":{"rendered":"Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia."},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Trophoblast fusion into the multinucleated syncytiotrophoblast (SCT) appears as an inescapable feature of placentation in mammals and other viviparous species. The trophoblast cells underlying the syncytium are considered a reservoir for the restoration of the aging peripheric structure. The transition from trophoblasts to SCTs has to be tightly regulated, and could be altered by genetic anomalies or environmental exposure. The resulting defective placental function could be one of the causes of the major placental diseases, such as preeclampsia (PE) and Intra-Uterine Growth Restriction (IUGR). This review attempts to take stock of the current knowledge about fusion mechanisms and their deregulations<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Int J Mol Sci. 2025 Mar 21;26(7): 2859.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8550","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/trophoblast-fusion-in-hypertensive-disorders-of-pregnancy-and-preeclampsia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Int J Mol Sci. 2025 Mar 21;26(7): 2859.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/trophoblast-fusion-in-hypertensive-disorders-of-pregnancy-and-preeclampsia\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-30T14:42:23+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/trophoblast-fusion-in-hypertensive-disorders-of-pregnancy-and-preeclampsia\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/trophoblast-fusion-in-hypertensive-disorders-of-pregnancy-and-preeclampsia\/\",\"name\":\"Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia. - 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