{"id":8548,"date":"2025-03-27T15:38:00","date_gmt":"2025-03-27T14:38:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8548"},"modified":"2025-06-30T15:49:57","modified_gmt":"2025-06-30T13:49:57","slug":"neurodevelopmental-out-comes-at-age-5-years-among-children-born-very-preterm-and-surviving-after-persistent-pulmonary-hypertension-of-the-new-born-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-out-comes-at-age-5-years-among-children-born-very-preterm-and-surviving-after-persistent-pulmonary-hypertension-of-the-new-born-epipage-2-cohort-study\/","title":{"rendered":"Neurodevelopmental out comes at age 5 years among children born very preterm and surviving after persistent pulmonary hypertension of the new born : EPIPAGE-2 cohort study"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Objective:<\/strong> to determine whether pulmonary hypertension (PH) is associated with higher risk of adverse neuro-<br>developmental outcome at age 5 in a population-based cohort of 22\u201331+6 preterm children.<br><strong>Study design <\/strong>: in the EPIPAGE-2 French prospective population-based cohort of preterm children born in 2011, the neurodevelopmental outcome of children with PH was collected at 5 years. The primary outcome was a com-<br>posite measure with four levels of neurodevelopmental disabilities: severe, moderate, mild, no disability, based<br>on cerebral palsy, visual, hearing or cognitive deficiencies, behavioral difficulties and developmental coordi-<br>nation disorders. Secondary outcomes were autism spectrum disorders and school attendance. Missing data were multiply imputed. Developmental measures were compared using generalized estimating equations models.<br><strong>Results<\/strong> : Of the 3007 eligible children, 1825 were analyzed, of whom 79 (4.3 %) were PH+. At age 5, 36.9 % (95<br>% CI, 26.0\u201347.8) of PH + children had moderate to severe overall neurodevelopmental disabilities compared<br>with 17.9 % (95 % CI, 16.1\u201319.8) of PH\u2013children, P &lt; 0.001. Significant differences at 5 years between the PH+<br>and PH\u2013 groups were observed for cerebral palsy (CP) (6 % versus 2.3 % for severe CP, P = 0.003), cognitive<br>deficiency (31.7 % versus 15.0 %, P &lt; 0.001) and developmental coordination disorders (27.1 % versus 11.7 %,<br>P &lt; 0.001). There were no significant differences in behavioral difficulties and autism spectrum disorders.<br>Normal school was attended by 69.2 % of PH + children versus 88.3 % of PH\u2013 children.<br><strong>Conclusion <\/strong>: In this nationwide population-based cohort of extremely preterm and very preterm infants, moderate to severe overall neurodevelopmental disability at age 5 was significantly associated with neonatal PH.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eur J Paediatr Neurol. 2025 Mar; 55:103-110.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8548","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neurodevelopmental out comes at age 5 years among children born very preterm and surviving after persistent pulmonary hypertension of the new born : EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-out-comes-at-age-5-years-among-children-born-very-preterm-and-surviving-after-persistent-pulmonary-hypertension-of-the-new-born-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neurodevelopmental out comes at age 5 years among children born very preterm and surviving after persistent pulmonary hypertension of the new born : EPIPAGE-2 cohort study - 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