{"id":8547,"date":"2025-05-21T15:23:00","date_gmt":"2025-05-21T13:23:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8547"},"modified":"2025-06-30T15:33:26","modified_gmt":"2025-06-30T13:33:26","slug":"incidence-risk-factors-and-outcomes-of-sars-cov-2-infection-in-pregnant-women-the-coropreg-population-based-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/incidence-risk-factors-and-outcomes-of-sars-cov-2-infection-in-pregnant-women-the-coropreg-population-based-study\/","title":{"rendered":"Incidence, Risk Factors and Outcomes of SARS-CoV-2 Infection in Pregnant Women : The COROPREG Population-Based Study"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">ABSTRACT<\/h2>\n\n\n\n<p><strong>Background<\/strong> : population-based data are needed to reliably assess the impact of SARS-CoV-2 infection during pregnancy.<\/p>\n\n\n\n<p><strong>Objectives <\/strong> : to estimate the population-based incidence of SARS-CoV-2 infection and its severe forms in the obstetric population, identify risk factors of severe SARS-CoV-2 infection (severe COVID-19) and describe delivery, maternal and neonatal outcomes by disease severity, using a definition of severity based on organ dysfunction.<\/p>\n\n\n\n<p><strong>Methods<\/strong> : a prospective population-based study conducted over the three first pandemic waves between March 2020 and April 2021 in 281 maternity hospitals in six French regions included all women with SARS-CoV-2 infection during pregnancy or within 7\u2009days post-partum, whether symptomatic or not, hospitalised or not. Severe COVID-19 forms were defined a priori using clinical, biological and management criteria of organ dysfunction. We calculated infection and severe infection rates and studied associations between sociodemographic, medical and pregnancy characteristics and severe COVID-19 by univariate and multivariate modified Poisson regression modelling.<\/p>\n\n\n\n<p><strong>Results<\/strong> : from a population of 385,214 deliveries in the participating regions, 6015 women with SARS-CoV-2 infection were identified, including 337 severe cases. The rates of severe COVID-19 were 1.1, 0.9 and 3.6 per 1000 deliveries during the first, second and third pandemic waves, respectively, and the proportions of severe COVID-19 were 8.6%, 3.4% and 9.3%, respectively. On multivariate analysis, the risk of severe COVID-19 was associated with younger and older age, migrant status, living with >\u20094 people, overweight or obesity, chronic hypertension or diabetes and infection \u2265\u200922\u2009weeks of gestation rather than earlier in pregnancy. Neonatal morbidity occurred mostly with severe maternal infection.<\/p>\n\n\n\n<p><strong>Conclusion : <\/strong>Using an organ-based definition of severity and population-based data, rates of severe COVID-19 appeared lower than in previous studies. A permanent perinatal surveillance system is needed to assess efficiently and rapidly the impact of future pandemics.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paediatr Perinat Epidemiol. 2025 May 21<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8547","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Incidence, Risk Factors and Outcomes of SARS-CoV-2 Infection in Pregnant Women : The COROPREG Population-Based Study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/incidence-risk-factors-and-outcomes-of-sars-cov-2-infection-in-pregnant-women-the-coropreg-population-based-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Incidence, Risk Factors and Outcomes of SARS-CoV-2 Infection in Pregnant Women : The COROPREG Population-Based Study - 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