{"id":8546,"date":"2025-05-06T15:01:00","date_gmt":"2025-05-06T13:01:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8546"},"modified":"2025-06-30T15:20:11","modified_gmt":"2025-06-30T13:20:11","slug":"treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/","title":{"rendered":"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Results:<\/strong> in both cohorts, treatment with inhaled nitric oxide was not associated with IQ at age 5\u20136\u2009years. Analysis identified maternal educational level, gestational age at discharge from hospital, intraventricular haemorrhage and maternal country of birth as important factors associated with IQ scores.<\/p>\n\n\n\n<p><strong>Aim : <\/strong>To investigate whether treatment with inhaled nitric oxide is associated with cognitive performance at age 5\u20136\u2009years in preterm-born children.<\/p>\n\n\n\n<p><strong>Methods : <\/strong>we analysed preterm children from two large European cohort studies, the German Neonatal Network (GNN) (<em>N<\/em>\u2009=\u20093606) and the French EPIPAGE-2 cohort (<em>N<\/em>\u2009=\u20092579) admitted to neonatal care and followed up at age 5\u20136\u2009years. Both cohorts had recorded data on iNO treatment. General cognitive ability was tested with IQ tests. Classification and Regression trees analysis was used to identify prenatal, perinatal and neonatal, clinical and social-environmental predictors of IQ.<\/p>\n\n\n\n<p><strong>Conclusion :<\/strong> Treatment with inhaled nitric oxide was neither negatively nor positively associated with IQ at age 5\u20136\u2009years. Neonatal and brain health, as well as socioeconomic factors are important for cognitive performance in early childhood.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acta Paediatr. 2025 May 6.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8546","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Acta Paediatr. 2025 May 6.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-30T13:20:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/\",\"name\":\"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2025-05-06T13:01:00+00:00\",\"dateModified\":\"2025-06-30T13:20:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/","og_locale":"en_US","og_type":"article","og_title":"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts - FHU Prem&#039;IMPACT","og_description":"Acta Paediatr. 2025 May 6.","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2025-06-30T13:20:11+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/","name":"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2025-05-06T13:01:00+00:00","dateModified":"2025-06-30T13:20:11+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/treatment-with-inhaled-nitric-oxide-and-general-intelligence-in-preterm-children-in-two-european-cohorts\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts"}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"Acta Paediatr. 2025 May 6.","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/8546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=8546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}