{"id":8543,"date":"2025-04-02T11:41:00","date_gmt":"2025-04-02T09:41:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8543"},"modified":"2025-08-29T11:46:40","modified_gmt":"2025-08-29T09:46:40","slug":"total-and-free-placental-growth-factor-levels-during-preeclampsia-and-fetal-growth-restriction","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/total-and-free-placental-growth-factor-levels-during-preeclampsia-and-fetal-growth-restriction\/","title":{"rendered":"Health-related quality of life at 5 years of age for children born very preterm with congenital anomalies: a multi-national cohort study."},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<h6 class=\"wp-block-heading\">Background<\/h6>\n\n\n\n<p id=\"Par1\">This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Methods<\/h6>\n\n\n\n<p id=\"Par2\">The study used data from a European cohort of children born very preterm (&lt;32 weeks of gestation) and followed up to 5 years of age (<em>N<\/em>\u2009=\u20093493). Multilevel Ordinary Least Squares (OLS) regression were used to explore the associations between the presence and severity of congenital anomalies.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Results<\/h6>\n\n\n\n<p id=\"Par3\">The mean total PedsQL\u2122 GCS score for children with a mild congenital anomaly was lower than the respective value for children without a congenital anomaly by 3.7 points (<em>p<\/em>\u2009&lt;\u20090.05), controlling for socioeconomic variables only; this effect was attenuated when accumulatively adjusting for perinatal characteristics (3.3 points (<em>p<\/em>\u2009&lt;\u20090.05)) and neonatal morbidities (3.1 (<em>p<\/em>\u2009&lt;\u20090.05)). The mean total PedsQL\u2122 GCS scores for children who had a severe congenital anomaly were lower by 7.1 points (<em>p<\/em>\u2009&lt;\u20090.001), 6.6 points (<em>p<\/em>\u2009&lt;\u20090.001) and 6.0 points (<em>p<\/em>\u2009&lt;\u20090.001) when accumulatively adjusting for socioeconomic, perinatal and neonatal variables, respectively.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">Conclusion<\/h6>\n\n\n\n<p>This study revealed that the presence and severity of congenital anomalies are significant predictors of HRQoL outcomes in children born very preterm<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pediatr Res. 2025 Apr;97(5):1711-1721. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8543","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Health-related quality of life at 5 years of age for children born very preterm with congenital anomalies: a multi-national cohort study. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/total-and-free-placental-growth-factor-levels-during-preeclampsia-and-fetal-growth-restriction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Health-related quality of life at 5 years of age for children born very preterm with congenital anomalies: a multi-national cohort study. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Pediatr Res. 2025 Apr;97(5):1711-1721.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/total-and-free-placental-growth-factor-levels-during-preeclampsia-and-fetal-growth-restriction\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-29T09:46:40+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/total-and-free-placental-growth-factor-levels-during-preeclampsia-and-fetal-growth-restriction\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/total-and-free-placental-growth-factor-levels-during-preeclampsia-and-fetal-growth-restriction\/\",\"name\":\"Health-related quality of life at 5 years of age for children born very preterm with congenital anomalies: a multi-national cohort study. - 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