{"id":8540,"date":"2025-02-18T17:18:00","date_gmt":"2025-02-18T16:18:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8540"},"modified":"2025-09-08T11:44:04","modified_gmt":"2025-09-08T09:44:04","slug":"neurodevelopmental-outcomes-at-five-years-in-children-born-very-preterm-24-31-weeks-exposed-to-opioids-with-or-without-midazolam-results-from-the-french-nationwide-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-outcomes-at-five-years-in-children-born-very-preterm-24-31-weeks-exposed-to-opioids-with-or-without-midazolam-results-from-the-french-nationwide-epipage-2-cohort-study\/","title":{"rendered":"Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam results from the French nationwide EPIPAGE 2 cohort study"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Background :<\/strong> data on preschool neurodevelopment of preterm infants according to the duration of their neonatal exposure to opioids with\/without midazolam is limited. We aimed to assess neurodevelopment outcome in children aged five years, born very preterm (24\u201331 weeks), according to exposure to these drugs.<\/p>\n\n\n\n<p><strong>Methods<\/strong> : secondary analysis from the French prospective cohort study EPIPAGE-2 (Etude Epid\u00e9miologique sur les Petits Ages Gestationnels, 2011). Exposure to opioids with\/without midazolam was classified as none, \u22647 or >7 days. Percentages were weighted to account for the study design. The primary outcome was moderate\/severe neurodevelopmental disabilities (NDD). Analyses were conducted using logistic regression and adjusted for perinatal confounders.<\/p>\n\n\n\n<p><strong>Findings:<\/strong> among 3117 survivors, 1165 (35.9%) were exposed (762\/1165 (68.0%) \u22647 days, 403\/1165 (32.0%) >7 days). Of these 49.5% received opioids only, 41.4% opioids and midazolam, and 9.1% midazolam only. Moderate\/severe NDD occurred in 17.8%, 18.9%, and 31.7% in the unexposed, exposed \u22647 days, and exposed >7 days groups, respectively. After adjustment for baseline confounders, only exposure >7 days was associated with increased rates of moderate\/severe NDD (adjusted odds ratio 2.07; 95% CI 1.32\u20133.26). After additional adjustment for severe neonatal morbidities no significant association was found between any duration of exposure and NDD.<\/p>\n\n\n\n<p><strong>Interpretation<\/strong>:Exposure to opioids with\/without midazolam >7 days might be associated with a higher prevalence of moderate\/severe NDD at five years in very preterm born children but severe neonatal morbidities are a major modulator of this association.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lancet Reg Health Eur 2025 Feb 18 52 101242.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8540","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam results from the French nationwide EPIPAGE 2 cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-outcomes-at-five-years-in-children-born-very-preterm-24-31-weeks-exposed-to-opioids-with-or-without-midazolam-results-from-the-french-nationwide-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam results from the French nationwide EPIPAGE 2 cohort study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Lancet Reg Health Eur 2025 Feb 18 52 101242.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-outcomes-at-five-years-in-children-born-very-preterm-24-31-weeks-exposed-to-opioids-with-or-without-midazolam-results-from-the-french-nationwide-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-08T09:44:04+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-outcomes-at-five-years-in-children-born-very-preterm-24-31-weeks-exposed-to-opioids-with-or-without-midazolam-results-from-the-french-nationwide-epipage-2-cohort-study\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/neurodevelopmental-outcomes-at-five-years-in-children-born-very-preterm-24-31-weeks-exposed-to-opioids-with-or-without-midazolam-results-from-the-french-nationwide-epipage-2-cohort-study\/\",\"name\":\"Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam results from the French nationwide EPIPAGE 2 cohort study - 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