{"id":8538,"date":"2025-04-03T16:57:00","date_gmt":"2025-04-03T14:57:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=8538"},"modified":"2025-06-27T17:06:31","modified_gmt":"2025-06-27T15:06:31","slug":"histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/","title":{"rendered":"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis."},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a \u2018maternal\u2010foetal rejection\u2019 mechanism, because at least some CHI cases fulfil the criteria for antibody\u2010mediated rejection (AMR) of kidney allografts according to the Banff classification [i.e. presence of anti\u2010human leukocyte antigen (HLA) paternal antibodies activating the complement or foetal\u2010specific antibodies (FSA), a macrophage\u2010rich infiltrate, and positive C4d immunostaining]. To gain further insights into CHI pathogenesis, we aimed to refine the phenotype of the inflammatory infiltrate using a multiplex immunofluorescence technique and to compare the mRNA signatures between CHI and AMR of kidney allografts. Twelve patients with C4d+\u2009FSA+ CHI were included in the study and compared to a control group of 5 patients without inflammatory lesions on placental examination. We developed a multiplex immunofluorescence panel to identify CD4+ and CD8+ T lymphocytes, CD68+\/CD206\u2212 and CD68+\/CD206+ macrophages, and NK cells in the villi and intervillous space. Molecular signatures were studied using NanoString\u00ae technology and the B\u2010HOT panel recommended by the Banff classification for kidney allografts. Multiplex immunofluorescence revealed that the infiltrate in the intervillous space was mainly composed of CD68+\/CD206\u2212 macrophages as well as a higher proportion of CD8+ lymphocytes in patients with CHI compared to controls. Densities of NK cells and CD4 T cells were very low. Molecular signatures showed an overexpression of HLA class II genes, an IFN\u2010\u03b3 signature, and cytokine gene sets in C4d+\u2009FSA+ CHI patients, also involved in kidney AMR. These results reinforce the paradigm of maternal\u2010foetal rejection.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>J Pathol. 2025 Jun;266(2):177-191.PMID: 40178007<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-8538","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"J Pathol. 2025 Jun;266(2):177-191.PMID: 40178007\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-27T15:06:31+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/\",\"name\":\"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis. - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2025-04-03T14:57:00+00:00\",\"dateModified\":\"2025-06-27T15:06:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis. - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/","og_locale":"en_US","og_type":"article","og_title":"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis. - FHU Prem&#039;IMPACT","og_description":"J Pathol. 2025 Jun;266(2):177-191.PMID: 40178007","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2025-06-27T15:06:31+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/","name":"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis. - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2025-04-03T14:57:00+00:00","dateModified":"2025-06-27T15:06:31+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/histologic-and-molecular-features-shared-between-antibody-mediated-rejection-of-kidney-allografts-and-chronic-histiocytic-intervillositis-support-common-pathogenesis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis."}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"J Pathol. 2025 Jun;266(2):177-191.PMID: 40178007","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/8538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=8538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}