{"id":7640,"date":"2024-04-30T15:59:20","date_gmt":"2024-04-30T13:59:20","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7640"},"modified":"2024-08-28T16:02:49","modified_gmt":"2024-08-28T14:02:49","slug":"analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/","title":{"rendered":"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:<\/strong> Show a prognostic value of brain changes in fetuses with intra uterine growth restriction (IUGR) on early neonatal outcome.<\/p>\n\n\n\n<p><strong>Study design:<\/strong> We prospectively recruited pregnant women whose fetuses presented fetal weight &lt; 5th centile. A brain MRI was performed between 28 and 32 weeks of gestation (WG). Several brain biometrics were measured (as fronto-occipital diameter (FOD) and transverse cerebellar diameter (TCD)). Neonatal prognosis was evaluated according to a composite criterion.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Of the 78 patients included, 62 had a fetal brain MRI. The mean centile value of FOD was lower in the unfavorable outcome group (n = 9) compared to the favorable outcome group (n = 53) (24.5 \u00b1 16.8 vs. 8.6 \u00b1 13.2, p = 0.004). The ROC curve for predicting risk of unfavorable neonatal outcome based on FOD presented an area under the curve of 0.81 (95 % CI, [0.63&#8212;0.99]) and a threshold determined at the 3rd centile was associated with sensitivity of 0.78 and a specificity of 0.89. In multivariate analysis, a FOD less than the 3rd centile was significantly associated with an unfavorable neonatal risk. There also was a reduction in TCD (25.5 \u00b1 21.5 vs. 10.4 \u00b1 10.4, p = 0.03) in the unfavorable neonatal outcome group.<\/p>\n\n\n\n<p><strong>Conclusion:<\/strong> We found an association between a reduction in FOD and TCD in fetal MRIs conducted between 28 and 32 WG in fetuses monitored for IUGR with an unfavorable neonatal outcome. Our results suggest that these biometric changes could constitute markers of poor neonatal prognosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p> Eur J Obstet Gynecol Reprod Biol . 2024 Jul:298:91-97 Epub 2024 Apr 30. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7640","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Eur J Obstet Gynecol Reprod Biol . 2024 Jul:298:91-97 Epub 2024 Apr 30.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-28T14:02:49+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/\",\"name\":\"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2024-04-30T13:59:20+00:00\",\"dateModified\":\"2024-08-28T14:02:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/","og_locale":"en_US","og_type":"article","og_title":"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study - FHU Prem&#039;IMPACT","og_description":"Eur J Obstet Gynecol Reprod Biol . 2024 Jul:298:91-97 Epub 2024 Apr 30.","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2024-08-28T14:02:49+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/","name":"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2024-04-30T13:59:20+00:00","dateModified":"2024-08-28T14:02:49+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/analysis-of-mri-brain-biometrics-in-fetuses-monitored-for-intra-uterine-growth-restriction-and-their-prognostic-value-results-of-a-prospective-multicenter-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"Analysis of MRI brain biometrics in fetuses monitored for intra uterine growth restriction and their prognostic value: Results of a prospective multicenter study"}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"Eur J Obstet Gynecol Reprod Biol . 2024 Jul:298:91-97 Epub 2024 Apr 30.","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/7640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=7640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}