{"id":7639,"date":"2024-07-02T15:56:07","date_gmt":"2024-07-02T13:56:07","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7639"},"modified":"2024-08-28T15:58:59","modified_gmt":"2024-08-28T13:58:59","slug":"mortality-and-neurodevelopmental-outcomes-at-2-years-corrected-age-of-very-preterm-infants-with-necrotising-enterocolitis-or-spontaneous-intestinal-perforation-the-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/mortality-and-neurodevelopmental-outcomes-at-2-years-corrected-age-of-very-preterm-infants-with-necrotising-enterocolitis-or-spontaneous-intestinal-perforation-the-epipage-2-cohort-study\/","title":{"rendered":"Mortality and neurodevelopmental outcomes at 2 years&#8217; corrected age of very preterm infants with necrotising enterocolitis or spontaneous intestinal perforation: The EPIPAGE-2 cohort study"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Purpose:<\/strong> The primary objective was to evaluate the impact of necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP) on mortality and neurodevelopmental outcomes at 2 years&#8217; corrected age (CA) in infants born before 32 weeks&#8217; gestation (WG).<\/p>\n\n\n\n<p><strong>Methods:<\/strong> We studied neurodevelopment at 2 years&#8217; CA of infants with NEC or SIP who were born before 32 WG from the EPIPAGE-2 cohort study. The primary outcome was death or the presence of moderate-to-severe motor or sensory disability defined by moderate-to-severe cerebral palsy or hearing or visual disability. The secondary outcome was developmental delay defined by a score &lt; 2 SDs below the mean for any of the five domains of the Ages and Stages Questionnaire.<\/p>\n\n\n\n<p><strong>Results:<\/strong> At 2 years&#8217; CA, 46% of infants with SIP, 34% of infants with NEC, and 14% of control infants died or had a moderate-to-severe sensorimotor disability (p &lt; 0.01). This difference was mainly due to an increase in in-hospital mortality in the infants with SIP or NEC. Developmental delay at 2 years&#8217; CA was more frequent for infants with SIP than controls (70.8% vs 44.0%, p = 0.02) but was similar for infants with NEC and controls (49.3% vs 44.0%, p = 0.5). On multivariate analysis, the likelihood of developmental delay was associated with SIP (adjusted odds ratio = 3.0, 95% CI 1.0-9.1) but not NEC as compared with controls.<\/p>\n\n\n\n<p><strong>Conclusion:<\/strong> NEC and SIP significantly increased the risk of death or sensorimotor disability at 2 years&#8217; CA. SIP was also associated with risk of developmental delay at 2 years&#8217; CA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eur J Pediatr . 2024 Sep;183(9):4019-4028. Epub 2024 Jul 2. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7639","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mortality and neurodevelopmental outcomes at 2 years&#039; corrected age of very preterm infants with necrotising enterocolitis or spontaneous intestinal perforation: The EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/mortality-and-neurodevelopmental-outcomes-at-2-years-corrected-age-of-very-preterm-infants-with-necrotising-enterocolitis-or-spontaneous-intestinal-perforation-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mortality and neurodevelopmental outcomes at 2 years&#039; corrected age of very preterm infants with necrotising enterocolitis or spontaneous intestinal perforation: The EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Eur J Pediatr . 2024 Sep;183(9):4019-4028. 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