{"id":7618,"date":"2024-04-02T13:21:18","date_gmt":"2024-04-02T11:21:18","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7618"},"modified":"2024-08-28T14:10:42","modified_gmt":"2024-08-28T12:10:42","slug":"early-mortality-cardiovascular-and-renal-diseases-in-womens-lives-following-hypertensive-disorders-of-pregnancy-the-prospective-nationwide-study-conception","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/early-mortality-cardiovascular-and-renal-diseases-in-womens-lives-following-hypertensive-disorders-of-pregnancy-the-prospective-nationwide-study-conception\/","title":{"rendered":"Early Mortality, Cardiovascular, and Renal Diseases in Women&#8217;s Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Background:<\/strong> We aimed to evaluate the impact of hypertensive disorders of pregnancy occurrence, recurrence, onset time, and severity on mortality and on a wide range of cardiovascular outcomes in France.<\/p>\n\n\n\n<p><strong>Methods and results:<\/strong> CONCEPTION (Cohort of Cardiovascular Diseases in Pregnancy) is a French nationwide prospective cohort using data from the National Health Data System. We included all women in CONCEPTION with no history of a cardiovascular event who delivered in France for the first time between 2010 and 2018 (N=2 819 655). Hypertensive disorders of pregnancy and cardiovascular outcomes during the study follow-up were identified using algorithms combining <em>International Classification of Diseases, Tenth Revision<\/em> (<em>ICD-10<\/em>) coded diagnoses during hospitalization and purchases of medication between 2010 and 2021. We fitted Cox models with time-varying exposure to assess the associations of hypertensive disorders of pregnancy with mortality and cardiovascular events. Women with gestational hypertension had a 1.25- to 2-fold higher risk of stroke, acute coronary syndrome, peripheral arterial disease, pulmonary embolism, and chronic kidney disease, and a 2- to 4-fold higher risk of rhythm and conduction disorder and heart failure. Women with preeclampsia had a 1.35- to 2-fold higher risk of rhythm or conduction disorder and pulmonary embolism during follow-up; a 2- to 4-fold higher risk of stroke, acute coronary syndrome, and peripheral arterial disease; and a 7- to 9-fold higher risk of heart failure and chronic kidney disease. They were 1.8 times more likely to die and 4.4 times more likely to die of cardiovascular causes.<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> Hypertensive disorders of pregnancy drastically increase the risk of mortality, cardiovascular, and renal events early after pregnancy. Recurrent, severe, and early-onset preeclampsia further increases this risk.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>J Am Heart Assoc. 2024 Apr 16;13(8):e033252.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7618","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Early Mortality, Cardiovascular, and Renal Diseases in Women&#039;s Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/early-mortality-cardiovascular-and-renal-diseases-in-womens-lives-following-hypertensive-disorders-of-pregnancy-the-prospective-nationwide-study-conception\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Early Mortality, Cardiovascular, and Renal Diseases in Women&#039;s Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION - 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