{"id":7551,"date":"2023-08-17T17:06:00","date_gmt":"2023-08-17T15:06:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7551"},"modified":"2024-05-07T17:09:02","modified_gmt":"2024-05-07T15:09:02","slug":"five-year-outcomes-for-extremely-preterm-babies-with-active-perinatal-management-a-clinical-prediction-model","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/five-year-outcomes-for-extremely-preterm-babies-with-active-perinatal-management-a-clinical-prediction-model\/","title":{"rendered":"Five-year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:<\/strong> To develop and validate a clinical prediction model for outcomes at 5 years of age for children born extremely preterm and receiving active perinatal management.<\/p>\n\n\n\n<p><strong>Design:<\/strong> The EPIPAGE-2 national prospective cohort.<\/p>\n\n\n\n<p><strong>Setting:<\/strong> France, 2011.<\/p>\n\n\n\n<p><strong>Population:<\/strong> Live-born neonates between 24<sup>+0<\/sup> and 26<sup>+6<\/sup> weeks of gestation who received active perinatal management (i.e. birth in a tertiary-level hospital, with antenatal steroids and resuscitation at birth).<\/p>\n\n\n\n<p><strong>Methods:<\/strong> A prediction model using logistic modelling, including gestational age, small-for gestational-age (SGA) status and sex, was developed. Model performance was assessed through calibration and discrimination, with bootstrap internal validation.<\/p>\n\n\n\n<p><strong>Main outcome measures:<\/strong> Survival without moderate or severe neurodevelopmental disability (NDD) at 5 years.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Among the 557 neonates included, 401 (72%) survived to 5 years, of which 59% survived without NDD (95% CI 54% to 63%). Predicted rates of survival without NDD ranged from 45% (95% CI 33% to 57%), to 56% (95% CI 49% to 64%) to 64% (95% CI 57% to 70%) for neonates born at 24, 25 and 26 weeks of gestation, respectively. Predicted rates of survival without NDD were 47% (95% CI 18% to 76%) and 62% (95% CI 49% to 76%) for SGA and non-SGA children, respectively. The model showed good calibration (calibration slope 0.85, 95% CI 0.54 to 1.16; calibration-in-the-large -0.0123, 95% CI -0.25 to 0.23) and modest discrimination (C-index 0.59, 95% CI 0.53 to 0.65).<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> A simple prediction model using three factors easily known antenatally may help doctors and families in their decision-making for extremely preterm neonates receiving active perinatal management.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BJOG. 2024 Jan;131(2):151-156. doi: 10.1111<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7551","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Five-year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/five-year-outcomes-for-extremely-preterm-babies-with-active-perinatal-management-a-clinical-prediction-model\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Five-year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model - 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