{"id":7542,"date":"2023-03-03T16:30:00","date_gmt":"2023-03-03T15:30:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7542"},"modified":"2024-05-07T16:35:19","modified_gmt":"2024-05-07T14:35:19","slug":"postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/","title":{"rendered":"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study."},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:<\/strong> To investigate whether extrauterine growth restriction (EUGR) during the neonatal hospitalisation by sex among extremely preterm (EPT) infants is associated with cerebral palsy (CP) and cognitive and motor abilities at 5 years of age.<\/p>\n\n\n\n<p><strong>Study design:<\/strong> Population-based cohort of births &lt;28 weeks of gestation with data from obstetric and neonatal records and parental questionnaires and clinical assessments at 5 years of age.<\/p>\n\n\n\n<p><strong>Setting:<\/strong> 11 European countries.<\/p>\n\n\n\n<p><strong>Patients:<\/strong> 957 EPT infants born in 2011-2012.<\/p>\n\n\n\n<p><strong>Main outcomes:<\/strong> EUGR at discharge from the neonatal unit was defined as (1) the difference between Z-scores at birth and discharge with &lt;-2 SD as severe, -2 to -1 SD as moderate using Fenton&#8217;s growth charts (Fenton) and (2) average weight-gain velocity using Patel&#8217;s formula in grams (g) per kilogram per day (Patel) with &lt;11.2 g (first quartile) as severe, 11.2-12.5 g (median) as moderate. Five-year outcomes were: a CP diagnosis, intelligence quotient (IQ) using the Wechsler Preschool and Primary Scales of Intelligence tests and motor function using the Movement Assessment Battery for Children, second edition.<\/p>\n\n\n\n<p><strong>Results:<\/strong> 40.1% and 33.9% children were classified as having moderate and severe EUGR, respectively, by Fenton and 23.8% and 26.3% by Patel. Among children without CP, those with severe EUGR had lower IQ than children without EUGR (-3.9 points, 95% Confidence Interval (CI)=-7.2 to -0.6 for Fenton and -5.0 points, 95% CI=-8.2 to -1.8 for Patel), with no interaction by sex. No significant associations were observed between motor function and CP.<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> Severe EUGR among EPT infants was associated with decreased IQ at 5 years of age.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):492-498. doi: 10.1136<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7542","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):492-498. doi: 10.1136\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-07T14:35:19+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/\",\"name\":\"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study. - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2023-03-03T15:30:00+00:00\",\"dateModified\":\"2024-05-07T14:35:19+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study. - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/","og_locale":"en_US","og_type":"article","og_title":"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study. - FHU Prem&#039;IMPACT","og_description":"Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):492-498. doi: 10.1136","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2024-05-07T14:35:19+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/","name":"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study. - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2023-03-03T15:30:00+00:00","dateModified":"2024-05-07T14:35:19+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/postnatal-growth-restriction-and-neurodevelopment-at-5-years-of-age-a-european-extremely-preterm-birth-cohort-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study."}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):492-498. doi: 10.1136","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/7542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=7542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}