{"id":7524,"date":"2023-03-14T14:49:00","date_gmt":"2023-03-14T13:49:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7524"},"modified":"2024-05-07T14:52:50","modified_gmt":"2024-05-07T12:52:50","slug":"second-trimester-amniotic-fluid-proteins-changes-in-subsequent-spontaneous-preterm-birth","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/second-trimester-amniotic-fluid-proteins-changes-in-subsequent-spontaneous-preterm-birth\/","title":{"rendered":"Second-trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth."},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Introduction:<\/strong> The global sequence of the pathogenesis of preterm labor remains unclear. This study aimed to compare amniotic fluid concentrations of extracellular matrix-related proteins (procollagen, osteopontin and IL-33), and of cytokines (IL-19, IL-6, IL-20, TNF\u03b1, TGF\u03b2, and IL-1\u03b2) in asymptomatic women with and without subsequent spontaneous preterm delivery.<\/p>\n\n\n\n<p><strong>Material and methods:<\/strong> We used amniotic fluid samples of singleton pregnancy, collected by amniocentesis between 16 and 20 weeks&#8217; gestation, without stigmata of infection (i.e., all amniotic fluid samples were tested with broad-range 16 S rDNA PCR to distinguish samples with evidence of past bacterial infection from sterile ones), during a randomized, double-blind, placebo-controlled trial to perform a nested case-control laboratory study. Cases were women with a spontaneous delivery before 37 weeks of gestation (preterm group). Controls were women who gave birth at or after 39 weeks (full term group). Amniotic fluid concentrations of the extracellular matrix-related proteins and cytokines measured by immunoassays were compared for two study groups.<\/p>\n\n\n\n<p><strong>Clinicaltrials:<\/strong> gov: <a href=\"http:\/\/clinicaltrials.gov\/show\/NCT00718705\">NCT00718705<\/a>.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Between July 2008 and July 2011, in 12 maternal-fetal medicine centers in France, 166 women with available PCR-negative amniotic fluid samples were retained for the analysis. Concentrations of procollagen, osteopontin, IL-19, IL-6, IL-20, IL-33, TNF\u03b1, TGF\u03b2, and IL-1\u03b2 were compared between the 37 who gave birth preterm and the 129 women with full-term delivery. Amniotic fluid levels of procollagen, osteopontin, IL-19, IL-33, and TNF\u03b1 were significantly higher in the preterm than the full-term group. IL-6, IL-20, TGF\u03b2, and IL-1\u03b2 levels did not differ between the groups.<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> In amniotic fluid 16 S rDNA PCR negative samples obtained during second-trimester amniocentesis, extracellular matrix-related protein concentrations (procollagen, osteopontin and IL-33), together with IL-19 and TNF\u03b1, were observed higher at this time in cases of later spontaneous preterm birth.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acta Obstet Gynecol Scand. 2023 May;102(5):597-604. doi: 10.1111<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7524","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Second-trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/second-trimester-amniotic-fluid-proteins-changes-in-subsequent-spontaneous-preterm-birth\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Second-trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth. - 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