{"id":7144,"date":"2023-04-01T16:13:00","date_gmt":"2023-04-01T14:13:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7144"},"modified":"2023-08-22T16:21:27","modified_gmt":"2023-08-22T14:21:27","slug":"intraventricular-hemorrhage-in-very-preterm-children-mortality-and-neurodevelopment-at-age-5","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/intraventricular-hemorrhage-in-very-preterm-children-mortality-and-neurodevelopment-at-age-5\/","title":{"rendered":"Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Objectives:<\/strong> The objectives were to describe mortality and causes of death in children with intraventricular hemorrhage (IVH) and to study neurodevelopmental outcomes.<\/p>\n\n\n\n<p><strong>Methods:<\/strong> The study was a secondary analysis of the French national prospective and population-based cohort EPIPAGE-2. Children were recruited in 2011. A standardized assessment was conducted at age 5. Children born before 32 weeks&#8217; gestation and admitted to a NICU were eligible. Exposure was IVH defined by the Papile classification. Main outcomes were mortality, causes of death, and neurodevelopmental outcomes at age 5.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Among the 3468 children included, 578 (16.7%) had grade 1 IVH, 424 (12.2%) grade 2 IVH, and 114 (3.3%) grade 3 IVH; 144 (4.1%) had intraparenchymal hemorrhage (IPH). Mortality was 29.7% (36 of 114) for children with grade 3 IVH and 74.4% (109 of 144) for those with IPH; 67.6% (21 of 31) and 88.7% (86 of 97) of deaths, respectively, were because of withholding and withdrawing of life-sustaining treatment. As compared with no IVH, low-grade IVH was not associated with measured neurodevelopmental disabilities at age 5. High-grade IVH was associated with moderate and severe neurodevelopmental disabilities, reduced full-scale IQ, and cerebral palsy.<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> Rates of neurodevelopmental disabilities at age 5 did not differ between children without IVH and those with low-grade IVH. For high-grade IVH, mortality rate was high, mostly because of withholding and withdrawal of life-sustaining treatment, and we found a strong association with overall neurodevelopmental disabilities in survivors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pediatric 2023 Apr 1;151(4):e2022059138. <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7144","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5 - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/intraventricular-hemorrhage-in-very-preterm-children-mortality-and-neurodevelopment-at-age-5\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5 - 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