{"id":7143,"date":"2023-02-21T15:50:00","date_gmt":"2023-02-21T14:50:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=7143"},"modified":"2023-08-22T16:12:37","modified_gmt":"2023-08-22T14:12:37","slug":"neonatal-necrotizing-enterocolitis-clostridium-butyricum-and-clostridium-neonatale-fermentation-metabolism-and-enteropathogenicity","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/neonatal-necrotizing-enterocolitis-clostridium-butyricum-and-clostridium-neonatale-fermentation-metabolism-and-enteropathogenicity\/","title":{"rendered":"Neonatal necrotizing enterocolitis: Clostridium butyricum and Clostridium neonatale fermentation metabolism and enteropathogenicity"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">ABSTRACT<\/h2>\n\n\n\n<p>Bacterial colonization in the gut plays a pivotal role in neonatal necrotizing enterocolitis (NEC) development, but the relationship between bacteria and NEC remains unclear. In this study, we aimed to elucidate whether bacterial butyrate end-fermentation metabolites participate in the development of NEC lesions and confirm the enteropathogenicity of <em>Clostridium butyricum<\/em> and <em>Clostridium neonatale<\/em> in NEC. First, we produced <em>C.butyricum<\/em> and <em>C.neonatale<\/em> strains impaired in butyrate production by genetically inactivating the <em>hbd<\/em> gene encoding \u03b2-hydroxybutyryl-CoA dehydrogenase that produces end-fermentation metabolites. Second, we evaluated the enteropathogenicty of the hbd-knockout strains in a gnotobiotic quail model of NEC. The analyses showed that animals harboring these strains had significantly fewer and less intense intestinal lesions than those harboring the respective wild-type strains. In the absence of specific biological markers of NEC, the data provide original and new mechanistic insights into the disease pathophysiology, a necessary step for developing potential novel therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gut Microbes. 2023 Jan-Dec;15(1):2172666<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-7143","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neonatal necrotizing enterocolitis: Clostridium butyricum and Clostridium neonatale fermentation metabolism and enteropathogenicity - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/neonatal-necrotizing-enterocolitis-clostridium-butyricum-and-clostridium-neonatale-fermentation-metabolism-and-enteropathogenicity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neonatal necrotizing enterocolitis: Clostridium butyricum and Clostridium neonatale fermentation metabolism and enteropathogenicity - 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