{"id":6467,"date":"2022-05-26T13:32:00","date_gmt":"2022-05-26T11:32:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=6467"},"modified":"2023-02-09T13:37:03","modified_gmt":"2023-02-09T12:37:03","slug":"a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/","title":{"rendered":"A <em>qnrD<\/em>-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in <em>Escherichia coli<\/em>"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Bacteria within biofilms may be exposed to sub-minimum inhibitory concentrations (sub-MICs) of antibiotics. Cell-to-cell contact within biofilms facilitates horizontal gene transfers and favors induction of the SOS response. Altogether, it participates in the emergence of antibiotic resistance. Aminoglycosides at sub-MICs can induce the SOS response through NO accumulation in <em>E. coli<\/em> carrying the small plasmid with the quinolone resistance <em>qnrD<\/em> gene (pDIJ09-518a). In this study, we show that in <em>E. coli<\/em> pDIJ09-518a, the SOS response triggered by sub-MICs of aminoglycosides has important consequences, promoting genetic rearrangement in class 1 integrons and biofilm formation. We found that the integrase expression was increased in <em>E. coli<\/em> carrying pDIJ09-518a in the presence of tobramycin, which was not observed for the WT isogenic strain that did not carry the <em>qnrD<\/em>-plasmid. Moreover, we showed that biofilm production was significantly increased in <em>E. coli<\/em> WT\/pDIJ09-518a compared to the WT strain. However, such a higher production was decreased when the Hmp-NO detoxification pathway was fully functional by overexpressing Hmp. Our results showing that a <em>qnrD<\/em>-plasmid can promote biofilm formation in <em>E. coli<\/em> and potentiate the acquisition and spread of resistance determinants for other antibiotics complicate the attempts to counteract antibiotic resistance and prevention of biofilm development even further. We anticipate that our findings emphasize the complex challenges that will impact the decisions about antibiotic stewardship, and other decisions related to retaining antibiotics as effective drugs and the development of new drugs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibiotics (Basel). 2022 May 26;11(6):715. doi: 10.3390\/antibiotics11060715. PMID: 35740122<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-6467","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Antibiotics (Basel). 2022 May 26;11(6):715. doi: 10.3390\/antibiotics11060715. PMID: 35740122\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-09T12:37:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/\",\"name\":\"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2022-05-26T11:32:00+00:00\",\"dateModified\":\"2023-02-09T12:37:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/","og_locale":"en_US","og_type":"article","og_title":"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli - FHU Prem&#039;IMPACT","og_description":"Antibiotics (Basel). 2022 May 26;11(6):715. doi: 10.3390\/antibiotics11060715. PMID: 35740122","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2023-02-09T12:37:03+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/","name":"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2022-05-26T11:32:00+00:00","dateModified":"2023-02-09T12:37:03+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/a-qnrd-plasmid-promotes-biofilm-formation-and-class-1-integron-gene-cassette-rearrangements-in-escherichia-coli\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"A qnrD-Plasmid Promotes Biofilm Formation and Class 1 Integron Gene Cassette Rearrangements in Escherichia coli"}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"Antibiotics (Basel). 2022 May 26;11(6):715. doi: 10.3390\/antibiotics11060715. PMID: 35740122","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/6467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=6467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}