{"id":6271,"date":"2022-03-26T11:54:00","date_gmt":"2022-03-26T10:54:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=6271"},"modified":"2023-01-03T11:58:37","modified_gmt":"2023-01-03T10:58:37","slug":"risk-factors-for-hypoxic-ischemic-encephalopathy-in-cases-of-severe-acidosis-a-case-control-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/risk-factors-for-hypoxic-ischemic-encephalopathy-in-cases-of-severe-acidosis-a-case-control-study\/","title":{"rendered":"Risk factors for hypoxic-ischemic encephalopathy in cases of severe acidosis: A case-control study"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Introduction:<\/strong> The aim of the study was to identify the obstetric risk factors for hypoxic-ischemic encephalopathy (HIE) in infants with asphyxia at birth.<\/p>\n\n\n\n<p><strong>Material and methods:<\/strong> This multicenter case-control study covered the 5-year period from 2014 through 2018 and included newborns \u226536 weeks of gestation with an umbilical pH at birth \u22647.0. Cases were newborns who developed moderate or severe HIE; they were matched with controls with pH \u22647.0 at birth over the same period without moderate or severe HIE. The factors studied were maternal, gestational, intrapartum, delivery-related, and neonatal characteristics. A multivariable analysis was performed to study the maternal, obstetric, and neonatal factors independently associated with moderate or severe HIE.<\/p>\n\n\n\n<p><strong>Results:<\/strong> Our review of the records identified 41 cases and 98 controls. Compared with controls, children with moderate or severe HIE had a lower 5-min Apgar score, lower umbilical artery pH, and higher cord lactate levels at birth and at 1 h of life. Obstetric factors associated with moderate or severe HIE were the occurrence of an acute event (adjusted odds ratio [aOR] 6.4; 95% confidence interval [CI] 1.8-22.5), maternal fever (aOR 3.5; 95% CI 1.0-11.9), and thick meconium during labor (aOR 2.9; 95% CI 1.0-8.6).<\/p>\n\n\n\n<p><strong>Conclusions:<\/strong> HIE is associated with a lower 5-min Apgar score and with the severity of acidosis at birth and at 1 h of life. In newborns with a pH &lt;7.0 at birth, the occurrence of an acute obstetric event, maternal fever, and thick meconium are independent factors associated with moderate or severe HIE.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acta Obstet Gynecol Scand. 2022 Apr;101(4):471-478<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-6271","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Risk factors for hypoxic-ischemic encephalopathy in cases of severe acidosis: A case-control study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/risk-factors-for-hypoxic-ischemic-encephalopathy-in-cases-of-severe-acidosis-a-case-control-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Risk factors for hypoxic-ischemic encephalopathy in cases of severe acidosis: A case-control study - 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