{"id":4996,"date":"2021-12-21T12:40:00","date_gmt":"2021-12-21T11:40:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=4996"},"modified":"2022-03-09T12:47:57","modified_gmt":"2022-03-09T11:47:57","slug":"early-antibiotic-exposure-and-adverse-outcomes-in-very-preterm-infants-at-low-risk-of-early-onset-sepsis-the-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/early-antibiotic-exposure-and-adverse-outcomes-in-very-preterm-infants-at-low-risk-of-early-onset-sepsis-the-epipage-2-cohort-study\/","title":{"rendered":"Early Antibiotic Exposure and Adverse Outcomes in Very Preterm Infants at Low Risk of Early-Onset Sepsis: The EPIPAGE-2 Cohort Study"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:&nbsp;<\/strong>To assess the association between early empirical antibiotics and neonatal adverse outcomes in very preterm infants without risk factors for early-onset sepsis (EOS).<\/p>\n\n\n\n<p><strong>Study design:&nbsp;<\/strong>This is a secondary analysis of the EPIPAGE-2 study, a prospective national population-based cohort that included all liveborn infants at 22-31 completed weeks of gestation in France in 2011. Infants at high risk of EOS (ie, born after preterm labor or preterm premature rupture of membranes or from a mother who had clinical chorioamnionitis or had received antibiotics during the last 72 hours) were excluded. Early antibiotic exposure was defined as antibiotic therapy started at day 0 or day 1 of life, irrespective of the duration and type of antibiotics. We compared treated and untreated patients using inverse probability of treatment weighting based on estimated propensity scores.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Among 648 very preterm infants at low risk of EOS, 173 (26.2%) had received early antibiotic treatment. Early antibiotic exposure was not associated with death or late-onset sepsis or necrotizing enterocolitis (OR, 1.04; 95% CI, 0.72-1.50); however, it was associated with higher odds of severe cerebral lesions (OR, 2.71; 95% CI, 1.25-5.86) and moderate-severe bronchopulmonary dysplasia (BPD) (OR, 2.30; 95% CI, 1.21-4.38).<\/p>\n\n\n\n<p><strong>Conclusions:&nbsp;<\/strong>Early empirical antibiotic therapy administrated in very preterm infants at low risk of EOS was associated with a higher risk of severe cerebral lesions and moderate-severe BPD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>J Pediatr. 2021 Dec 21:S0022-3476(21)01223-3. doi: 10.1016\/j.jpeds.2021.11.075. Epub ahead of print. PMID: 34942178.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-4996","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Early Antibiotic Exposure and Adverse Outcomes in Very Preterm Infants at Low Risk of Early-Onset Sepsis: The EPIPAGE-2 Cohort Study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/early-antibiotic-exposure-and-adverse-outcomes-in-very-preterm-infants-at-low-risk-of-early-onset-sepsis-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Early Antibiotic Exposure and Adverse Outcomes in Very Preterm Infants at Low Risk of Early-Onset Sepsis: The EPIPAGE-2 Cohort Study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"J Pediatr. 2021 Dec 21:S0022-3476(21)01223-3. doi: 10.1016\/j.jpeds.2021.11.075. 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