{"id":4595,"date":"2021-09-01T16:36:00","date_gmt":"2021-09-01T14:36:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=4595"},"modified":"2021-11-30T16:38:33","modified_gmt":"2021-11-30T15:38:33","slug":"nebulized-curcumin-protects-neonatal-lungs-from-antenatal-insult-in-rats-2","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/nebulized-curcumin-protects-neonatal-lungs-from-antenatal-insult-in-rats-2\/","title":{"rendered":"Nebulized curcumin protects neonatal lungs from antenatal insult in rats"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Intrauterine growth restriction (IUGR) increases the risk of bronchopulmonary dysplasia (BPD), one of the major complications of prematurity. Antenatal low-protein diet (LPD) exposure in rats induces IUGR and mimics BPD-related alveolarization disorders. Peroxisome proliferator-activated receptor-\u03b3 (PPAR\u03b3) plays a key role in normal lung development and was found deregulated following LPD exposure. The objective of this article was to investigate the effects of nebulized curcumin, a natural PPAR\u03b3 agonist, to prevent IUGR-related abnormal lung development. We studied rat pups antenatally exposed to an LPD or control diet (CTL) and treated with nebulized curcumin (50 mg\/kg) or vehicle from&nbsp;<em>postnatal<\/em>&nbsp;(<em>P<\/em>)&nbsp;<em>days 1<\/em>&nbsp;to&nbsp;<em>5<\/em>. The primary readouts were lung morphometric analyses at&nbsp;<em>P21<\/em>. Immunohistochemistry (<em>P21<\/em>) and microarrays (<em>P6<\/em>&nbsp;and&nbsp;<em>P11<\/em>) were compared within animals exposed to LPD versus controls, with and without curcumin treatment. Quantitative morphometric analyses revealed that LPD induced abnormal alveolarization as evidenced by a significant increase in mean linear intercept (MLI) observed in&nbsp;<em>P21<\/em>&nbsp;LPD-exposed animals. Early curcumin treatment prevented this effect, and two-way ANOVA analysis demonstrated significant interaction between diet and curcumin both for MLI [<em>F<\/em><sub>(1,39)<\/sub>&nbsp;= 12.67,&nbsp;<em>P<\/em>&nbsp;= 0.001] and radial alveolar count at&nbsp;<em>P21<\/em>&nbsp;[<em>F<\/em><sub>(1,40)<\/sub>&nbsp;= 6.065,&nbsp;<em>P<\/em>&nbsp;= 0.0182]. Immunohistochemistry for fatty acid binding protein 4 (FABP4), a major regulator of PPAR\u03b3 pathway, showed a decreased FABP4<sup>+<\/sup>&nbsp;alveolar cell density in LPD-exposed animals treated by curcumin. Transcriptomic analysis showed that early curcumin significantly prevented the activation of profibrotic pathways observed at&nbsp;<em>P11<\/em>&nbsp;in LPD-exposed animals. Nebulized curcumin appears to be a promising strategy to prevent alveolarization disorders in IUGR rat pups, targeting pathways involved in lung development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Am J Physiol Lung Cell Mol Physiol. 2021 Sep 1;321(3):L545-L552. doi: 10.1152\/ajplung.00195.2021. Epub 2021 Jun 23. PMID: 34159801.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-4595","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nebulized curcumin protects neonatal lungs from antenatal insult in rats - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/nebulized-curcumin-protects-neonatal-lungs-from-antenatal-insult-in-rats-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nebulized curcumin protects neonatal lungs from antenatal insult in rats - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Am J Physiol Lung Cell Mol Physiol. 2021 Sep 1;321(3):L545-L552. doi: 10.1152\/ajplung.00195.2021. 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