{"id":4586,"date":"2021-11-30T12:58:30","date_gmt":"2021-11-30T11:58:30","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=4586"},"modified":"2021-11-30T12:58:32","modified_gmt":"2021-11-30T11:58:32","slug":"megacystis-in-the-first-trimester-of-pregnancy-prognostic-factors-and-perinatal-outcomes","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/megacystis-in-the-first-trimester-of-pregnancy-prognostic-factors-and-perinatal-outcomes\/","title":{"rendered":"Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:&nbsp;<\/strong>To determine whether bladder size is associated with an unfavorable neonatal outcome, in the case of first-trimester megacystis.<\/p>\n\n\n\n<p><strong>Materials and methods:&nbsp;<\/strong>This was a retrospective observational study between 2009 and 2019 in two prenatal diagnosis centers. The inclusion criterion was an enlarged bladder (&gt; 7 mm) diagnosed at the first ultrasound exam between 11 and 13+6 weeks of gestation. The main study endpoint was neonatal outcome based on bladder size. An adverse outcome was defined by the completion of a medical termination of pregnancy, the occurrence of in utero fetal death, or a neonatal death. Neonatal survival was considered as a favorable outcome and was defined by a live birth, with or without normal renal function, and with a normal karyotype.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Among 75 cases of first-trimester megacystis referred to prenatal diagnosis centers and included, there were 63 (84%) adverse outcomes and 12 (16%) live births. Fetuses with a bladder diameter of less than 12.5 mm may have a favorable outcome, with or without urological problems, with a high sensitivity (83.3%) and specificity (87.3%), area under the ROC curve = 0.93, 95% CI (0.86-0.99), p&lt; 0.001. Fetal autopsy was performed in 52 (82.5%) cases of adverse outcome. In the 12 cases of favorable outcome, pediatric follow-up was normal and non-pathological in 8 (66.7%).<\/p>\n\n\n\n<p><strong>Conclusion:&nbsp;<\/strong>Bladder diameter appears to be a predictive marker for neonatal outcome. Fetuses with smaller megacystis (7-10 mm) have a significantly higher chance of progressing to a favorable outcome. Urethral stenosis and atresia are the main diagnoses made when first-trimester megacystis is observed. Karyotyping is important regardless of bladder diameter.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PLoS One. 2021 Sep 7;16(9):e0255890. doi: 10.1371\/journal.pone.0255890. PMID: 34492029; PMCID: PMC8423287.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-4586","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/megacystis-in-the-first-trimester-of-pregnancy-prognostic-factors-and-perinatal-outcomes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"PLoS One. 2021 Sep 7;16(9):e0255890. doi: 10.1371\/journal.pone.0255890. 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