{"id":4582,"date":"2021-02-15T12:09:00","date_gmt":"2021-02-15T11:09:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=4582"},"modified":"2021-11-30T12:42:01","modified_gmt":"2021-11-30T11:42:01","slug":"mid-trimester-miscarriage-and-subsequent-pregnancy-outcomes-the-role-of-cervical-insufficiency-in-a-cohort-of-175-cases","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/mid-trimester-miscarriage-and-subsequent-pregnancy-outcomes-the-role-of-cervical-insufficiency-in-a-cohort-of-175-cases\/","title":{"rendered":"Mid-trimester miscarriage and subsequent pregnancy outcomes: the role of cervical insufficiency in a cohort of 175 cases"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:&nbsp;<\/strong>To evaluate the causes of MTM and their impact on subsequent pregnancies.<\/p>\n\n\n\n<p><strong>Material and methods:&nbsp;<\/strong>A retrospective single-center cohort study of all pregnancies with a second-trimester pregnancy loss between 14 weeks and 21 weeks + 6 days gestation, excluding terminations of pregnancy (TOP) and in utero fetal deaths. Predefined criteria were used to allocate cases to one of 6 primary etiologic diagnoses: cervical insufficiency, chorioamnionitis, placental anomalies, fetal anomalies, iatrogenic causes, or abdominal trauma.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Among 578 mid-trimester fetal losses, 175 were MTM, a prevalence of 5.7 per 1000 live births in the center. The suspected primary cause was cervical insufficiency in 76 cases (43.4%), chorioamnionitis in 59 (33.7%), placental anomalies or preterm premature rupture of membranes in 26 (14.8%), iatrogenic in 8 (4.6%), trauma in 3 (1.7%), and undetermined in 3 cases (1.7%). A subsequent pregnancy beyond 14 WG was recorded for 78 patients. Recurrent MTM occurred in 21.8% and preterm deliveries in 14.1% ; 13% of patients without evidence of cervical insufficiency in the index pregnancy required emergency cerclage.<\/p>\n\n\n\n<p><strong>Conclusion:&nbsp;<\/strong>Cervical insufficiency was the leading cause of MTM, with a high risk of recurrent MTM or preterm birth, thus prophylactic cerclage or cervical length measurements should be considered for subsequent pregnancies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p> J Matern Fetal Neonatal Med. 2021 Feb 15:1-6. doi: 10.1080\/14767058.2020.1861600. Epub ahead of print. PMID: 33588670.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-4582","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mid-trimester miscarriage and subsequent pregnancy outcomes: the role of cervical insufficiency in a cohort of 175 cases - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/mid-trimester-miscarriage-and-subsequent-pregnancy-outcomes-the-role-of-cervical-insufficiency-in-a-cohort-of-175-cases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mid-trimester miscarriage and subsequent pregnancy outcomes: the role of cervical insufficiency in a cohort of 175 cases - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"J Matern Fetal Neonatal Med. 2021 Feb 15:1-6. doi: 10.1080\/14767058.2020.1861600. 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