{"id":4531,"date":"2021-06-06T16:55:00","date_gmt":"2021-06-06T14:55:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=4531"},"modified":"2021-11-23T19:11:49","modified_gmt":"2021-11-23T18:11:49","slug":"strategies-for-assessing-the-impact-of-loss-to-follow-up-on-estimates-of-neurodevelopmental-impairment-in-a-very-preterm-cohort-at-2-years-of-age","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/strategies-for-assessing-the-impact-of-loss-to-follow-up-on-estimates-of-neurodevelopmental-impairment-in-a-very-preterm-cohort-at-2-years-of-age\/","title":{"rendered":"Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Background:&nbsp;<\/strong>Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the impact of loss to follow-up on the estimated prevalence of neurodevelopmental impairment in a VPT cohort using different methodological approaches.<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>This study includes births &lt; 32 weeks of gestational age (GA) from 4 regions in the UK and Portugal participating in a European birth cohort (N = 1737 survivors). Data on maternal characteristics, pregnancy complications, neonatal outcomes and neighborhood deprivation were collected at baseline. Neurodevelopment was assessed at 2 years of corrected age (CA) using standardized parent-report measures. We applied (1) multiple imputation (MI) and (2) inverse probability weighting (IPW) to estimate the impact of non-response on the prevalence of moderate to severe neurodevelopmental impairment and assessed violations of the missing at random (MAR) assumption using the delta method.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>54.2% of children were followed-up. Follow-up was less likely when mothers were younger, multiparous, foreign-born, did not breastfeed and came from deprived areas. The prevalence of neurodevelopmental impairment was 18.4% (95% confidence interval (CI):15.9-21.1) and increased to 20.4% (95%CI: 17.3-23.4) and 20.0% (95%CI:16.9-23.1) for MI and IPW models, respectively. Simulating strong violations of MAR (children with impairments being 50% less likely to be followed-up) raised estimates to 23.6 (95%CI:20.1-27.1) CONCLUSIONS: In a VPT cohort with high loss to follow-up, correcting for attrition yielded modest increased estimates of neurodevelopmental impairment at 2 years CA; estimates were relatively robust to violations of the MAR assumption.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BMC Med Res Methodol. 2021 Jun 6;21(1):118. doi: 10.1186\/s12874-021-01264-3. PMID: 34092226; PMCID: PMC8182922.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-4531","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/strategies-for-assessing-the-impact-of-loss-to-follow-up-on-estimates-of-neurodevelopmental-impairment-in-a-very-preterm-cohort-at-2-years-of-age\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"BMC Med Res Methodol. 2021 Jun 6;21(1):118. doi: 10.1186\/s12874-021-01264-3. 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