{"id":4059,"date":"2021-06-23T12:51:00","date_gmt":"2021-06-23T10:51:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=4059"},"modified":"2021-07-22T12:54:15","modified_gmt":"2021-07-22T10:54:15","slug":"nebulized-curcumin-protects-neonatal-lungs-from-antenatal-insult-in-rats","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/nebulized-curcumin-protects-neonatal-lungs-from-antenatal-insult-in-rats\/","title":{"rendered":"Nebulized curcumin protects neonatal lungs from antenatal insult in rats."},"content":{"rendered":"\n<h4 class=\"wp-block-heading\"> Abstract<\/h4>\n\n\n\n<p><strong>Rationale:&nbsp;<\/strong>Intrauterine growth restriction (IUGR) increases the risk of bronchopulmonary dysplasia (BPD), one of the major complications of prematurity. Antenatal low-protein diet (LPD) exposure in rats induces IUGR and mimics BPD-related alveolarization disorders. Proliferator-activated receptor (PPARg) plays a key role in normal lung development and was found deregulated following LPD exposure.<\/p>\n\n\n\n<p><strong>Objectives:&nbsp;<\/strong>Investigate the effects of nebulized curcumin, a natural PPARg agonist, to prevent IUGR-related abnormal lung development.<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>We studied rat pups antenatally exposed to an LPD or control diet (CTL) and treated with nebulized curcumin (50 mg\/kg) or vehicle from postnatal (P) days 1 to 5. The primary readouts were lung morphometric analyses at P21. Immunohistochemistry (P21) and microarrays (P6 and P11) were compared within animals exposed to LPD versus controls, with and without curcumin treatment.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Quantitative morphometric analyses revealed that LPD induced abnormal alveolarization as evidenced by a significant increase in Mean Linear Intercept (MLI) observed in P21 LPD-exposed animals. Early curcumin treatment prevented this effect and two-way ANOVA analysis demonstrated significant interaction between diet and curcumin both for MLI (F<sub>(1,39)<\/sub>=12.67,p=0.001) and Radial Alveolar Count at P21 (F<sub>(1,40)<\/sub>= 6.065, p=0.0182). Immunohistochemistry for FABP4, a major regulator of PPARg pathway showed a decreased FABP4<sup>+<\/sup>&nbsp;alveolar cell density in LPD-exposed animals treated by curcumin. Transcriptomic analysis showed that early curcumin significantly prevented the activation of pro-fibrotic pathways observed at P11 in LPD-exposed animals.<\/p>\n\n\n\n<p><strong>Conclusion:&nbsp;<\/strong>Nebulized curcumin appears to be a promising strategy to prevent alveolarization disorders in IUGR rat pups, targeting pathways involved in lung development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Am J Physiol Lung Cell Mol Physiol. 2021 Jun 23. doi: 10.1152\/ajplung.00195.2021. Epub ahead of print. PMID: 34159801.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-4059","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nebulized curcumin protects neonatal lungs from antenatal insult in rats. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/nebulized-curcumin-protects-neonatal-lungs-from-antenatal-insult-in-rats\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nebulized curcumin protects neonatal lungs from antenatal insult in rats. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Am J Physiol Lung Cell Mol Physiol. 2021 Jun 23. doi: 10.1152\/ajplung.00195.2021. 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