{"id":385,"date":"2019-01-18T18:08:05","date_gmt":"2019-01-18T17:08:05","guid":{"rendered":"http:\/\/fhu-prema.local\/?post_type=publication&p=385"},"modified":"2020-12-01T15:18:36","modified_gmt":"2020-12-01T14:18:36","slug":"aspirin-andpreeclampsia","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/aspirin-andpreeclampsia\/","title":{"rendered":"Aspirin and preeclampsia"},"content":{"rendered":"\n

Presse Med.2019 Jan;48(1 Pt 1):34-45. doi: 10.1016\/j.lpm.2018.11.022. Epub2019 Jan 18<\/p>\n\n\n\n

Indications for aspirin during pregnancy are a matter of debate and there is a recent trend to an extended prescription and an overuse of aspirin in pregnancy. Aspirin is efficient in secondary prevention of preeclampsia essentially in patients with a personal history of preeclampsia. The effect of aspirin on platelet aggregation and on the TXA2\/PGI2 balance is dose-dependent. The optimum dosage, from 75mg\/day to 150mg\/day, needs to be determined. Fetal safety data at 150mg\/day are still limited. The efficacy of aspirin seems to be subject to a chronobiological effect. It is recommended to prescribe an evening or bedtime intake. Aspirin, in primary prevention of preeclampsia, given to high-risk patients identified in the first trimester by screening tests, seems to reduce the occurrence of early-on set preeclampsia. Nevertheless, there are insufficient data for the implementation of such screening procedures in practice.<\/p>\n","protected":false},"excerpt":{"rendered":"

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