{"id":384,"date":"2019-10-18T17:58:02","date_gmt":"2019-10-18T15:58:02","guid":{"rendered":"http:\/\/fhu-prema.local\/?post_type=publication&#038;p=384"},"modified":"2020-12-01T15:28:58","modified_gmt":"2020-12-01T14:28:58","slug":"degrelle-sachissey-astepanian-afournier-tguibourdenche-jmandelbrot-ltsatsarisv","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/degrelle-sachissey-astepanian-afournier-tguibourdenche-jmandelbrot-ltsatsarisv\/","title":{"rendered":"Association of serum angiogenic factors with bronchopulmonary dysplasia. The ANGIODYS cohort study"},"content":{"rendered":"\n<p>Pregnancy Hypertens.2019Oct;18:82-87. doi: 10.1016\/j.preghy.2019.09.015. Epub 2019 Sep 29<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Objectives<\/h4>\n\n\n\n<p>Angiogenic factors may be involved in lung development. To evaluate the relations between maternal and cordblood angiogenic factors (sflt-1, placental growth factor [plgf], soluble endogline [seng], transforming growthfactor \u03b2 [TGF-beta]) and their association with moderate and severe broncho-pulmonary dysplasia (BPD) invery preterm growth-restricted infants.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Study design<\/h4>\n\n\n\n<p>Prospective mono-centric cohort study. Twenty-four mother-child dyads featuring antepartumpreeclampsia,intra-uterine growth restriction (IUGR) and birth before 30 weeks&#8217; gestation were included. This ensured a 80%power to test whether sflt-1 maternal levels would be twice as high in cases of BPD as in the absence of BPD.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Main outcome measures<\/h4>\n\n\n\n<p>Four pro\/anti-angiogenic factors from two pathways (sflt-1, plgf and seng, TGF-beta) were measured inmaternal serum before delivery (at the time of hospitalization or the day of birth) and in neonates&#8217; cord blood.Neonatal outcome was moderate to severe BPD, defined as oxygen requirement for at least 28 days and persistent need for oxygen or ventilatory support at 36 weeks&#8217; postmenstrual age.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Results<\/h4>\n\n\n\n<p>Sflt-1 levels were positively correlated in maternal serum and cord blood (rs = 0.83, p &lt; .001) but levels of plgfand TGF-beta and its receptor seng were not. Among all the factors studied in cord and maternal blood, nonewas associated with BPD.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Conclusions<\/h4>\n\n\n\n<p>In IUGR preterm babies born before 30 weeks&#8217; gestation from pre-eclamptic mothers, serum sflt-1, plgf andseng, TGF-\u03b2 levels were not correlated with BPD. The increased BPD risk in preterm neonates born from pre-eclamptic mothers cannot be related to high sflt-1 levels.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pregnancy Hypertens.2019Oct;18:82-87. doi: 10.1016\/j.preghy.2019.09.015. Epub 2019 Sep 29<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-384","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Association of serum angiogenic factors with bronchopulmonary dysplasia. The ANGIODYS cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/degrelle-sachissey-astepanian-afournier-tguibourdenche-jmandelbrot-ltsatsarisv\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association of serum angiogenic factors with bronchopulmonary dysplasia. The ANGIODYS cohort study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Pregnancy Hypertens.2019Oct;18:82-87. doi: 10.1016\/j.preghy.2019.09.015. 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