{"id":375,"date":"2018-12-05T17:16:13","date_gmt":"2018-12-05T16:16:13","guid":{"rendered":"http:\/\/fhu-prema.local\/?post_type=publication&#038;p=375"},"modified":"2020-12-01T15:17:54","modified_gmt":"2020-12-01T14:17:54","slug":"intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/","title":{"rendered":"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30514388#\" class=\"ek-link\">BMC Med. 2018 Dec 5;16(1):227. doi: 10.1186\/s12916-018-1206-4.<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">BACKGROUND:<\/h4>\n\n\n\n<p>Emerging evidence suggests intensity of perinatal care influences survival for extremely preterm babies. We evaluated the effect of differences in perinatal care intensity between centres on sensorimotor morbidity at 2 years of age. We hypothesised that hospitals with a higher intensity of perinatal care would have improved survival without increased disability.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">METHODS:<\/h4>\n\n\n\n<p>Foetuses alive at maternal admission to a level 3 hospital in France in 2011, subsequently delivered between 22 and 26 weeks gestational age (GA) and included in the EPIPAGE-2 national prospective observational cohort study formed the baseline population. Level of intensity of perinatal care was assigned according to hospital of birth, categorised into three groups using &#8216;perinatal intensity&#8217; ratios (ratio of 24-25 weeks GA babies admitted to neonatal intensive care to foetuses of the same GA alive at maternal admission to hospital). Multiple imputation was used to account for missing data; hierarchical logistic regression accounting for births nested within centres was then performed.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">RESULTS:<\/h4>\n\n\n\n<p>One thousand one hundred twelve foetuses were included; 473 survived to 2 years of age (126 of 358 in low-intensity, 140 of 380 in medium-intensity and 207 of 374 in high-intensity hospitals). There were no differences in disability (adjusted odds ratios 0.93 (95% CI 0.28 to 3.04) and 1.04 (95% CI 0.34 to 3.14) in medium- and high- compared to low-intensity hospitals, respectively). Compared to low-intensity hospitals, survival without sensorimotor disability was increased in the population of foetuses alive at maternal admission to hospital and in live-born babies, but there were no differences when considering only babies admitted to NICU or survivors.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">CONCLUSIONS:<\/h4>\n\n\n\n<p>No difference in sensorimotor outcome for survivors of extremely preterm birth at 2 years of age was found according to the intensity of perinatal care provision. Active management of periviable births was associated with increased survival without sensorimotor disability.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BMC Med. 2018 Dec 5;16(1):227. doi: 10.1186\/s12916-018-1206-4.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-375","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"BMC Med. 2018 Dec 5;16(1):227. doi: 10.1186\/s12916-018-1206-4.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:site_name\" content=\"FHU Prem&#039;IMPACT\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-01T14:17:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/\",\"name\":\"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT\",\"isPartOf\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\"},\"datePublished\":\"2018-12-05T16:16:13+00:00\",\"dateModified\":\"2020-12-01T14:17:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/fhu-premimpact.org\/en\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#website\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"name\":\"FHU PREM'IMPACT\",\"description\":\"Perinatal inflammation and prematurity\",\"publisher\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#organization\",\"name\":\"FHU PREM'IMPACT\",\"url\":\"https:\/\/fhu-premimpact.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"contentUrl\":\"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg\",\"width\":1280,\"height\":720,\"caption\":\"FHU PREM'IMPACT\"},\"image\":{\"@id\":\"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/fhupremimpact\/\",\"https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/","og_locale":"en_US","og_type":"article","og_title":"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT","og_description":"BMC Med. 2018 Dec 5;16(1):227. doi: 10.1186\/s12916-018-1206-4.","og_url":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/","og_site_name":"FHU Prem&#039;IMPACT","article_modified_time":"2020-12-01T14:17:54+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/","url":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/","name":"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study - FHU Prem&#039;IMPACT","isPartOf":{"@id":"https:\/\/fhu-premimpact.org\/en\/#website"},"datePublished":"2018-12-05T16:16:13+00:00","dateModified":"2020-12-01T14:17:54+00:00","breadcrumb":{"@id":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fhu-premimpact.org\/en\/publications\/intensity-of-perinatal-care-extreme-prematurity-and-sensorimotor-outcome-at-2-years-corrected-age-evidence-from-the-epipage-2-cohort-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/fhu-premimpact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/fhu-premimpact.org\/en\/publications\/"},{"@type":"ListItem","position":3,"name":"Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study"}]},{"@type":"WebSite","@id":"https:\/\/fhu-premimpact.org\/en\/#website","url":"https:\/\/fhu-premimpact.org\/en\/","name":"FHU PREM'IMPACT","description":"Perinatal inflammation and prematurity","publisher":{"@id":"https:\/\/fhu-premimpact.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fhu-premimpact.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/fhu-premimpact.org\/en\/#organization","name":"FHU PREM'IMPACT","url":"https:\/\/fhu-premimpact.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","contentUrl":"https:\/\/fhu-premimpact.org\/wp-content\/uploads\/2025\/03\/logo-grand-centre-fhupremimpact.jpg","width":1280,"height":720,"caption":"FHU PREM'IMPACT"},"image":{"@id":"https:\/\/fhu-premimpact.org\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/fhupremimpact\/","https:\/\/www.linkedin.com\/in\/fhu-prem-impact-ap-hp-inserm-universit-paris-cit-70b911253\/"]}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"post-thumbnail":false,"twentytwenty-fullscreen":false},"uagb_author_info":{"display_name":"Laurence Lecomte","author_link":"https:\/\/fhu-premimpact.org\/en\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"BMC Med. 2018 Dec 5;16(1):227. doi: 10.1186\/s12916-018-1206-4.","_links":{"self":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication\/375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/types\/publication"}],"wp:attachment":[{"href":"https:\/\/fhu-premimpact.org\/en\/wp-json\/wp\/v2\/media?parent=375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}