{"id":3485,"date":"2020-05-29T12:44:00","date_gmt":"2020-05-29T10:44:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=3485"},"modified":"2021-03-04T12:50:36","modified_gmt":"2021-03-04T11:50:36","slug":"circulating-cytokines-associated-with-poor-pregnancy-outcomes-in-beninese-exposed-to-infection-with-plasmodium-falciparum","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/circulating-cytokines-associated-with-poor-pregnancy-outcomes-in-beninese-exposed-to-infection-with-plasmodium-falciparum\/","title":{"rendered":"Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with Plasmodium falciparum."},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p>Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies, including our own, suggested that placental and peripheral cytokine and chemokine levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters, and these studies do not address the effect of different cytokines in peripheral blood plasma samples taken at early and midpregnancy and at delivery. Here, we aimed to investigate whether peripheral plasma cytokine levels were associated with pregnancy outcomes in a cohort of 400 Beninese pregnant women. Using a high-sensitivity cytometry-based method, we quantified the levels of interleukin-4 (IL-4), IL-5, IL-10, IL-12p70, and gamma interferon (IFN-\u03b3) in peripheral plasma samples taken at two time points during pregnancy and at delivery in various groups of pregnant women identified with <em>Plasmodium falciparum<\/em> infection, with anemia, with preterm births, or giving birth to babies who are small for their gestational age. We found that, consistently at all time points, elevated levels of IL-10 were strongly and significantly associated with <em>P. falciparum<\/em> infection, while the levels of IFN-\u03b3 at inclusion and delivery were weakly but also significantly associated. Low levels of IL-5 at delivery were associated with a greater risk of both preterm births and small-for-gestational-age babies. The immunosuppressive effects of IL-10 likely affect the overall cytokine equilibrium during pregnancy in women harboring <em>P. falciparum<\/em> infections. Our findings highlight the peripheral signature of pregnancy outcomes and strengthen the idea of using cytokines as diagnostic or prognostic markers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Infect Immun. 2020 Jul 21;88(8):e00042-20. doi: 10.1128\/IAI.00042-20. PMID: 32513854; PMCID: PMC7375769.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3485","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with Plasmodium falciparum. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/circulating-cytokines-associated-with-poor-pregnancy-outcomes-in-beninese-exposed-to-infection-with-plasmodium-falciparum\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with Plasmodium falciparum. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Infect Immun. 2020 Jul 21;88(8):e00042-20. doi: 10.1128\/IAI.00042-20. 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