{"id":3196,"date":"2020-02-11T12:49:00","date_gmt":"2020-02-11T11:49:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=3196"},"modified":"2021-11-23T16:31:24","modified_gmt":"2021-11-23T15:31:24","slug":"the-impact-of-chorionicity-on-pregnancy-outcome-and-neurodevelopment-at-2-years-old-among-twins-born-preterm-the-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/the-impact-of-chorionicity-on-pregnancy-outcome-and-neurodevelopment-at-2-years-old-among-twins-born-preterm-the-epipage-2-cohort-study\/","title":{"rendered":"The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study."},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:&nbsp;<\/strong>To compare the short- and mid-term outcomes of preterm twins by chorionicity of pregnancy.<br><strong>Design:&nbsp;<\/strong>Prospective nationwide population-based EPIPAGE-2 cohort study.<br><strong>Setting:&nbsp;<\/strong>546 maternity units in France, between March and December 2011.<br><strong>Population:&nbsp;<\/strong>A total of 1700 twin neonates born between 24 and 34 weeks of gestation.<br><strong>Methods:&nbsp;<\/strong>The association of chorionicity with outcomes was analysed using multivariate regression models.<br><strong>Main outcome measures:&nbsp;<\/strong>First, survival at 2-year corrected age with or without neurosensory impairment, and second, perinatal, short-, and mid-term outcomes (survival at discharge, survival at discharge without severe morbidity) were described and compared by chorionicity.<br><strong>Results:&nbsp;<\/strong>In the EPIPAGE 2 cohort, 1700 preterm births were included (850 twin pregnancies). In all, 1220 (71.8%) were from dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC pregnancies had three times more medical terminations than DC pregnancies (1.67 versus 0.51%, P &lt; 0.001), whereas there were three times more stillbirths in MC than in DC pregnancies (10.09 versus 3.78%, P &lt; 0.001). Both twins were alive at birth in 86.6% of DC pregnancies compared with 80.0% among MC pregnancies (P = 0.008). No significant difference according to chorionicity was found regarding neonatal deaths and morbidities. Likewise, for children born earlier than 32 weeks, the 2-year follow-up neurodevelopmental results were not significantly different between DC and MC twins.<br><strong>Conclusions:&nbsp;<\/strong>This study confirms that MC pregnancies have a higher risk of adverse outcomes. However, the outcomes among preterm twins admitted to neonatal intensive care units are similar irrespective of chorionicity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BJOG. 2021 Jan;128(2):281-291. doi: 10.1111\/1471-0528.16170. Epub 2020 Mar 12. PMID: 32048439.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-3196","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study. - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/the-impact-of-chorionicity-on-pregnancy-outcome-and-neurodevelopment-at-2-years-old-among-twins-born-preterm-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study. - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"BJOG. 2021 Jan;128(2):281-291. doi: 10.1111\/1471-0528.16170. 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