{"id":2581,"date":"2020-07-01T17:08:41","date_gmt":"2020-07-01T15:08:41","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=2581"},"modified":"2020-11-25T17:10:48","modified_gmt":"2020-11-25T16:10:48","slug":"association-of-chorioamnionitis-with-cerebral-palsy-at-two-years-after-spontaneous-very-preterm-birth-the-epipage-2-cohort-study","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/association-of-chorioamnionitis-with-cerebral-palsy-at-two-years-after-spontaneous-very-preterm-birth-the-epipage-2-cohort-study\/","title":{"rendered":"Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study"},"content":{"rendered":"\n<p>J Pediatr.\u00a02020 Jul;222:71-78.e6.\u00a0doi: 10.1016\/j.jpeds.2020.03.021.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p><strong>Objective:&nbsp;<\/strong>To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years&#8217; corrected age in infants born before 32 weeks of gestation after spontaneous birth.<\/p>\n\n\n\n<p><strong>Study design:&nbsp;<\/strong>EPIPAGE-2 is a national, prospective, population-based cohort study of children born preterm in France in 2011; recruitment periods varied by gestational age. This analysis includes infants born alive after preterm labor or preterm premature rupture of membranes from 24<sup>0\/7<\/sup>&nbsp;to 31<sup>6\/7<\/sup>&nbsp;weeks of gestation. We compared the outcomes of CP, death at 2 years&#8217; corrected age, and &#8220;CP or death at age 2&#8221; according to the presence of either clinical chorioamnionitis or histologic chorioamnionitis. All percentages were weighted by the duration of the recruitment period.<\/p>\n\n\n\n<p><strong>Results:&nbsp;<\/strong>Among 2252 infants born alive spontaneously before 32 weeks of gestation, 116 (5.2%) were exposed to clinical chorioamnionitis. Among 1470 with placental examination data available, 639 (43.5%) had histologic chorioamnionitis. In total, 346 infants died before 2 years and 1586 (83.2% of the survivors) were evaluated for CP at age 2 years. CP rates were 11.1% with and 5.0% without clinical chorioamnionitis (P = .03) and 6.1% with and 5.3% without histologic chorioamnionitis (P = .49). After adjustment for confounding factors, CP risk rose with clinical chorioamnionitis (aOR 2.13, 95% CI 1.12-4.05) but not histologic chorioamnionitis (aOR 1.21, 95% 0.75-1.93). Neither form was associated with the composite outcome &#8220;CP or death at age 2.&#8221;<\/p>\n\n\n\n<p><strong>Conclusions:&nbsp;<\/strong>Among infants very preterm born spontaneously, the risk of CP at a corrected age of 2 years was associated with exposure to clinical chorioamnionitis but not histologic chorioamnionitis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>J Pediatr. 2020 Jul;222:71-78.e6. doi: 10.1016\/j.jpeds.2020.03.021. PMID: 32586536.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-2581","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/association-of-chorioamnionitis-with-cerebral-palsy-at-two-years-after-spontaneous-very-preterm-birth-the-epipage-2-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"J Pediatr. 2020 Jul;222:71-78.e6. doi: 10.1016\/j.jpeds.2020.03.021. 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