{"id":2324,"date":"2020-07-13T10:38:33","date_gmt":"2020-07-13T08:38:33","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=2324"},"modified":"2020-11-25T13:31:51","modified_gmt":"2020-11-25T12:31:51","slug":"uptake-of-cerium-dioxide-nanoparticles-and-impact-on-viability-differentiation-and-functions-of-primary-trophoblast-cells-from-human-placenta","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/uptake-of-cerium-dioxide-nanoparticles-and-impact-on-viability-differentiation-and-functions-of-primary-trophoblast-cells-from-human-placenta\/","title":{"rendered":"Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta"},"content":{"rendered":"\n<p>Nanomaterials (Basel). 2020 Jul 3;10(7):1309. doi: 10.3390\/nano10071309. PMID: 32635405<\/p>\n\n\n\n<p>Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta &#8211; PubMed<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p>The human placenta is at the interface between maternal and fetal circulations, and is crucial for fetal development. The nanoparticles of cerium dioxide (CeO<sub>2<\/sub> NPs) from air pollution are an unevaluated risk during pregnancy. Assessing the consequences of placenta exposure to CeO<sub>2<\/sub> NPs could contribute to a better understanding of NPs&#8217; effect on the development and functions of the placenta and pregnancy outcome. We used primary villous cytotrophoblasts purified from term human placenta, with a wide range of CeO<sub>2<\/sub> NPs concentrations (0.1-101 \u03bcg\/cm<sup>2<\/sup>) and exposure time (24-72 h), to assess trophoblast uptake, toxicity and impact on trophoblast differentiation and endocrine function. We have shown the capacity of both cytotrophoblasts and syncytiotrophoblasts to internalize CeO<sub>2<\/sub> NPs. CeO<sub>2<\/sub> NPs affected trophoblast metabolic activity in a dose and time dependency, induced caspase activation and a LDH release in the absence of oxidative stress. CeO<sub>2<\/sub> NPs decreased the fusion capacity of cytotrophoblasts to form a syncytiotrophoblast and disturbed secretion of the pregnancy hormones hCG, hPL, PlGF, P4 and E2, in accordance with NPs concentration. This is the first study on the impact of CeO<sub>2<\/sub> NPs using human primary trophoblasts that decrypts their toxicity and impact on placental formation and functions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nanomaterials (Basel). 2020 Jul 3;10(7):1309. doi: 10.3390\/nano10071309. PMID: 32635405<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-2324","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/uptake-of-cerium-dioxide-nanoparticles-and-impact-on-viability-differentiation-and-functions-of-primary-trophoblast-cells-from-human-placenta\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Nanomaterials (Basel). 2020 Jul 3;10(7):1309. doi: 10.3390\/nano10071309. 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