{"id":2132,"date":"2020-03-23T15:31:00","date_gmt":"2020-03-23T14:31:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=2132"},"modified":"2020-11-26T15:57:38","modified_gmt":"2020-11-26T14:57:38","slug":"maternal-obesity-and-severe-preeclampsia-among-immigrant-women-a-mediation-analysis","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/maternal-obesity-and-severe-preeclampsia-among-immigrant-women-a-mediation-analysis\/","title":{"rendered":"Maternal obesity and severe preeclampsia among immigrant women: a mediation analysis"},"content":{"rendered":"\n<p>Scientific Reports (2020), 10:5215. https:\/\/doi.org\/10.1038\/s41598-020-62032-9<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<p>We investigated the extent to which pre-pregnancy obesity mediates the association between maternal place of birth and severe pre-eclampsia in the PreCARE cohort of pregnant women in Paris (n = 9,579).<br>Adjusted path analysis logistic regression models were used to assess the role of pre-pregnancy obesity as a mediator in the association between maternal place of birth and the development of severe pre-eclampsia. We calculated 1. adjusted odds ratios and 95% confidence intervals for the total exposure-outcome association and for the direct and indirect\/obesity-mediated components 2. the indirect\/obesity-mediated effect. <br>Ninety-five (0.99%) women developed severe pre-eclampsia, 47.6% were non-European immigrants, 16.3% were born in Sub-Saharan Africa, and 12.6% were obese (BMI &gt; = 30 kg\/m2). Women experiencing severe pre-eclampsia were more likely to be from Sub-<br>Saharan Africa (p = 0.023) and be obese (p = 0.048). Mothers from Sub-Saharan Africa had an increased risk of severe pre-eclampsia compared to European-born mothers (aOR 2.53, 95% CI 1.39\u20134.58) and the obesity-mediated indirect effect was 18% of the total risk (aOR 1.18, 95%CI 1.03\u20131.35). <br>In conclusion, Sub-Saharan African immigrant women have a two-fold higher risk of developing severe pre-eclampsia as compared to European-born women, one-fifth of which is mediated by pre-pregnancy obesity. Our results quantify the potential benefit of decreasing obesity among at-risk women.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientific Reports (2020), 10:5215. https:\/\/doi.org\/10.1038\/s41598-020-62032-9<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-2132","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Maternal obesity and severe preeclampsia among immigrant women: a mediation analysis - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/maternal-obesity-and-severe-preeclampsia-among-immigrant-women-a-mediation-analysis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Maternal obesity and severe preeclampsia among immigrant women: a mediation analysis - 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