{"id":2057,"date":"2019-07-12T16:02:00","date_gmt":"2019-07-12T14:02:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=2057"},"modified":"2020-12-01T15:34:12","modified_gmt":"2020-12-01T14:34:12","slug":"ifitm-proteins-inhibit-placental-syncytiotrophoblast-formation-and-promote-fetal-demise","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/ifitm-proteins-inhibit-placental-syncytiotrophoblast-formation-and-promote-fetal-demise\/","title":{"rendered":"IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise"},"content":{"rendered":"\n<p>Science. 2019 Jul 12;365(6449):176-180. doi: 10.1126\/science.aaw7733. PMID: 31296770.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<p>Elevated levels of type I interferon (IFN) during pregnancy are associated with intrauterine growth retardation, preterm birth, and fetal demise through mechanisms that are not well understood. A critical step of placental development is the fusion of trophoblast cells into a multinucleated syncytiotrophoblast (ST) layer. Fusion is mediated by syncytins, proteins deriving from ancestral endogenous retroviral envelopes. Using cultures of human trophoblasts or mouse cells, we show that IFN-induced transmembrane proteins (IFITMs), a family of restriction factors blocking the entry step of many viruses, impair ST formation and inhibit syncytin-mediated fusion. Moreover, the IFN inducer polyinosinic: polycytidylic acid promotes fetal resorption and placental abnormalities in wild-type but not in <em>Ifitm-<\/em>deleted mice. Thus, excessive levels of IFITMs may mediate the pregnancy complications observed during congenital infections and other IFN-induced pathologies.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science. 2019 Jul 12;365(6449):176-180. doi: 10.1126\/science.aaw7733. PMID: 31296770.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-2057","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/ifitm-proteins-inhibit-placental-syncytiotrophoblast-formation-and-promote-fetal-demise\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise - FHU Prem&#039;IMPACT\" \/>\n<meta property=\"og:description\" content=\"Science. 2019 Jul 12;365(6449):176-180. doi: 10.1126\/science.aaw7733. 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