{"id":1323,"date":"2019-06-24T12:17:00","date_gmt":"2019-06-24T10:17:00","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=1323"},"modified":"2020-12-01T15:22:09","modified_gmt":"2020-12-01T14:22:09","slug":"high-level-of-soluble-human-leukocyte-antigen-hla-g-at-beginning-of-pregnancy-as-predictor-of-risk-of-malaria-during-infancy","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/high-level-of-soluble-human-leukocyte-antigen-hla-g-at-beginning-of-pregnancy-as-predictor-of-risk-of-malaria-during-infancy\/","title":{"rendered":"High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31235762\" class=\"ek-link\">Sci Rep. 2019 Jun 24;9(1):9160. doi: 10.<\/a>1038\/s41598-019-45688-w.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p>Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR\u2009=\u20091.02, 95%CI [1.01-1.03], p\u2009=\u20090.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sci Rep. 2019 Jun 24;9(1):9160. doi: 10.1038\/s41598-019-45688-w.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-1323","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/high-level-of-soluble-human-leukocyte-antigen-hla-g-at-beginning-of-pregnancy-as-predictor-of-risk-of-malaria-during-infancy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy - 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