{"id":1273,"date":"2019-09-19T17:53:16","date_gmt":"2019-09-19T15:53:16","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&p=1273"},"modified":"2020-12-01T15:35:34","modified_gmt":"2020-12-01T14:35:34","slug":"maternal-malaria-but-not-schistosomiasis-is-associated-with-a-higher-risk-of-febrile-infection-in-infant-during-the-first-3-months-of-life-a-mother-child-cohort-in-benin","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/maternal-malaria-but-not-schistosomiasis-is-associated-with-a-higher-risk-of-febrile-infection-in-infant-during-the-first-3-months-of-life-a-mother-child-cohort-in-benin\/","title":{"rendered":"Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin."},"content":{"rendered":"\n

PLoS One. 2019 Sep 19;14(9):e0222864. doi: 10.1371\/journal.pone.0222864. eCollection 2019.<\/a><\/p>\n\n\n\n

BACKGROUND:<\/h4>\n\n\n\n

Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection.<\/p>\n\n\n\n

METHODS:<\/h4>\n\n\n\n

In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)-determined monthly using a thick blood smear-and urinary schistosomiasis-determined once before pregnancy and once at delivery using urine filtration-were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and\/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic\/mixed linear regression models.<\/p>\n\n\n\n

RESULTS:<\/h4>\n\n\n\n

The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months.<\/p>\n\n\n\n

CONCLUSION:<\/h4>\n\n\n\n

We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.<\/p>\n","protected":false},"excerpt":{"rendered":"

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