{"id":1265,"date":"2019-12-13T15:36:55","date_gmt":"2019-12-13T14:36:55","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?post_type=publication&#038;p=1265"},"modified":"2020-12-01T15:24:50","modified_gmt":"2020-12-01T14:24:50","slug":"high-uptake-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-is-associated-with-improved-birth-weight-among-pregnant-women-in-ghana","status":"publish","type":"publication","link":"https:\/\/fhu-premimpact.org\/en\/publications\/high-uptake-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-is-associated-with-improved-birth-weight-among-pregnant-women-in-ghana\/","title":{"rendered":"High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31836735\">Sci Rep.<\/a> 2019 Dec 13;9(1):19034. doi: 10.1038\/s41598-019-55046-5.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Abstract<\/h4>\n\n\n\n<p>Despite the clinically proven advantages of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), utilisation has been low in many African countries. To increase uptake and achieve the desired effect, the World Health Organization revised the policy to a monthly administration. Assessing the coverage and impact of the revised policy on pregnancy and neonatal outcomes is, therefore, a necessity. A 2-parallel cross-sectional hospital-based study was carried out among pregnant women attending first antenatal care (ANC) and delivery. Maternal and cord blood samples were assayed for malaria parasites by quantitative PCR targeting both the 18S rDNA and the acidic terminal segment of Plasmodium falciparum var genes, and plasma SP levels were measured by liquid chromatography coupled to tandem mass spectrometry. Parasite prevalence was similar between the two study sites but decreased significantly between the first ANC (9% or 43%) and delivery (4% or 11%) based on the qPCR target. At delivery, 64.5% of women received \u22653 IPTp-SP dose, 15.5% received 2 doses and 6% had 1 dose. Taking \u22653 IPTp-SP doses was associated with an average birth weight increase of more than 0.165\u2009kg. IPTp-SP uptake was associated with plasma SP level at delivery (OR\u2009=\u200932.3, p\u2009\u2264\u20090.005, 95% CI (13.3;78.4) for those that reported \u22653 IPTp-SP doses) while the same trend of improved birth weight was observed with high plasma SP levels. The new IPTp policy is well implemented and well utilised by women in the sites considered in this study and translates to the improved birth weight observed. This study confirms the interest and the clinical benefit expected from this policy change.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sci Rep. 2019 Dec 13;9(1):19034. doi: 10.1038\/s41598-019-55046-5.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-1265","publication","type-publication","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana - FHU Prem&#039;IMPACT<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhu-premimpact.org\/en\/publications\/high-uptake-of-intermittent-preventive-treatment-of-malaria-in-pregnancy-is-associated-with-improved-birth-weight-among-pregnant-women-in-ghana\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana - 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