{"id":9357,"date":"2026-05-22T16:38:39","date_gmt":"2026-05-22T14:38:39","guid":{"rendered":"https:\/\/fhu-premimpact.org\/?page_id=9357"},"modified":"2026-05-22T16:46:19","modified_gmt":"2026-05-22T14:46:19","slug":"impact-du-depistage-de-la-preeclampsie-au-premier-trimestre-sur-la-morbidite-perinatale-et-maternelle-un-essai-randomise-multicentrique-copie-copie","status":"publish","type":"page","link":"https:\/\/fhu-premimpact.org\/en\/recherche\/impact-du-depistage-de-la-preeclampsie-au-premier-trimestre-sur-la-morbidite-perinatale-et-maternelle-un-essai-randomise-multicentrique-copie-copie\/","title":{"rendered":"VilliRNAseq"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Trajectoire transcriptomique cellulaire du placenta humain au cours de la grossesse<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Investigateur coordonnateur : <\/p>\n\n\n\n<p><a><strong>Vassilis Tsatsaris<\/strong><\/a> :Maternit\u00e9 de Port Royal,  H\u00f4pital Cochin AP-HP &#8211; Paris<\/p>\n\n\n\n<p>Responsable scientifique<\/p>\n\n\n\n<p><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-color\"><strong>C\u00e9line MEHATS<\/strong><\/mark> : Equipe FGTB, Institut Cochin, Inserm U1016-CNRS UMR8104-Universit\u00e9 Paris Cit\u00e9<\/p>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Justification scientifique<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Les nouvelles technologies de s\u00e9quen\u00e7age du transcriptome \u00e0 l\u2019\u00e9chelle de la cellule unique permettent de cartographier des populations de cellules et leur \u00e9tat \u00e0 un degr\u00e9 de r\u00e9solution \u00e9lev\u00e9, ainsi que de d\u00e9duire des fonctions, trajectoires et des interactions de ces populations. Nous avons d\u00e9velopp\u00e9 une approche single nucleus RNA-seq pour analyser le transcriptome placentaire \u00e0 partir de noyaux, pr\u00e9servant ainsi l\u2019int\u00e9grit\u00e9 du syncytium placentaire. Cette approche est r\u00e9alisable sur de petits fragments de villosit\u00e9s et offre pour la premi\u00e8re fois la possibilit\u00e9 d\u2019envisager la caract\u00e9risation de l\u2019expression g\u00e9nique au sein de l\u2019unit\u00e9 structurale du placenta humain au cours de la grossesse.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Objectifs<\/h3>\n\n\n\n<p>Objectif principal : Effectuer une analyse de la trajectoire transcriptomique cellulaire du placenta humain du premier trimestre de la grossesse jusqu\u2019\u00e0 l\u2019accouchement.<\/p>\n\n\n\n<p><br><br>Objectifs secondaires: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Constituer une collection de pr\u00e9l\u00e8vements placentaires longitudinaux au cours de la grossesse avec des \u00e9chantillons de villosit\u00e9s placentaires du premier trimestre de la grossesse (obtenues \u00e0 partir de biopsies de villosit\u00e9s choriales) et d\u2019\u00e9chantillons placentaires \u00e0 l\u2019accouchement quel que soit le terme (pr\u00e9l\u00e8vements placentaires \u00e0 l\u2019accouchement), avec recueil des issues de grossesse.<\/li>\n\n\n\n<li>Identifier des marqueurs pr\u00e9coces de complications de la grossesse (notamment pr\u00e9-\u00e9clampsie, RCIU, pr\u00e9maturit\u00e9) en lien avec une pathologie vasculaire placentaire.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Sch\u00e9ma exp\u00e9rimental<\/h3>\n\n\n\n<p>\u00c9tude monocentrique non interventionnelle.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Population concern\u00e9e<\/h3>\n\n\n\n<p>Patientes prises en charge dans le CPDPN de Cochin avec une demande de biopsie de villosit\u00e9s choriales (dans le cadre du soin) avec analyse cytog\u00e9n\u00e9tique ou de g\u00e9n\u00e9tique mol\u00e9culaire pour le diagnostic pr\u00e9natal d\u2019une pathologie g\u00e9n\u00e9tique.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Nombre de sujets s\u00e9lectionn\u00e9s<\/h3>\n\n\n\n<p>100 femmes.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Dur\u00e9e de la recherche<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>dur\u00e9e d\u2019inclusion&nbsp;: 24 mois<\/li>\n\n\n\n<li>dur\u00e9e d&#8217;observation de la patiente &nbsp;: 7 mois<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dur\u00e9e totale : 31 mois<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Nombre d\u2019inclusions pr\u00e9vues par centre et par mois<\/h3>\n\n\n\n<p>4 inclusions par mois<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">PROMOTEUR : AP-HP<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Source de financement : ANR<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Etat d&#8217;avancement <\/h3>\n\n\n\n<p><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-color\">L&#8217;\u00e9tude a d\u00e9marr\u00e9 le 25 mars 2026<\/mark>.<\/p>\n\n\n\n<p>Au 21 mai 2026, nous comptabilisons <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-color\"><strong>3 patientes <\/strong><\/mark>dans l&#8217;\u00e9tude.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trajectoire transcriptomique cellulaire du placenta humain au cours de la grossesse Investigateur coordonnateur : Vassilis Tsatsaris :Maternit\u00e9 de Port Royal, H\u00f4pital Cochin AP-HP &#8211; Paris Responsable scientifique C\u00e9line MEHATS : Equipe FGTB, Institut Cochin, Inserm U1016-CNRS UMR8104-Universit\u00e9 Paris Cit\u00e9 Justification scientifique Les nouvelles technologies de s\u00e9quen\u00e7age du transcriptome \u00e0 l\u2019\u00e9chelle de la cellule unique permettent [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":0,"parent":241,"menu_order":36,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-9357","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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